毛茛科植物石龙芮的化学成分研究  

Studies on the chemical constituents in herb of Ranunculus sceleratus

作　　者：高晓忠[1] 周长新[1] 张水利[1] 姚巍[2] 赵昱[1] 

机构地区：[1]浙江大学药学院中药与天然药物研究室 [2]浙江化工科技集团有限公司,浙江杭州310023

出　　处：《中国中药杂志》2005年第2期124-126,共3页China Journal of Chinese Materia Medica

基　　金：中国博士后基金 (2 0 0 1年第 2 9期 )

摘　　要：目的 :对毛茛科植物石龙芮Ranunculussceleratus的化学成分进行分离和结构鉴定。方法 :采用溶剂提取和各种色谱法分离得到 6个化合物 ,运用多种波谱技术 (EI-MS ,1H-NMR ,13 C-NMR ,DEPT谱 ,NOE差谱 )鉴定其化学结构。结果 :6个化合物分别鉴定为豆甾-4-烯 3,6-二酮 (stigmasta-4- ene 3,6 dione ,Ⅰ )、豆甾醇 (stigmasterol,Ⅱ )、6 羟基 7 甲氧基香豆素 (isoscopoletin ,Ⅲ )、七叶内酯二甲醚 (scoparone,Ⅳ )、原儿茶醛 (protocatechuicaldehyde ,Ⅴ )和原儿茶酸 (protocatechuicacid ,Ⅵ )。结论 :化合物Ⅰ ,Ⅲ ,Ⅳ ,Ⅴ 。Objective: To isolate and determine the chemical constituents from Ranunculus sceleratus. Method: Six compounds were isolated and purified by extraction and different kinds of column chromatography. The structures were determined on the basis of extensive spectral analysis such as EI-MS, ~1H-NMR, ^(13)C-NMR, DEPT and NOEDS. Result: The structures were elucidated as stigmasta-4-ene-3, 6-dione Ⅰ, stigmasterol Ⅱ, isoscopoletin Ⅲ, scoparone Ⅳ, protocatechuic aldehyde Ⅴand protocatechuic acid Ⅵ, respectively. Conclusion: Compound Ⅰ, Ⅲ, Ⅳ, Ⅴ and Ⅵ were isolated from R. genus for the first time.

关 键 词：化学成分 原儿茶酸 首次 原儿茶醛 分离 色谱法 结构鉴定 二甲醚 化合物 二酮 

分 类 号：R284.1[医药卫生—中药学]