麝香酮的2种不同包合物及脂质体载体经皮扩散比较研究  

Study of diffusion of muscone in different inclusion complexes and liposome through rat skin in vitro

作　　者：狄留庆[1] 毛春芹[1] 谢辉[1] 郭戎[1] 薛明[1] 燕珂[1] 张莉[1] 郦红岩[1] 

机构地区：[1]南京中医药大学,江苏南京210029

出　　处：《中国中药杂志》2005年第4期260-263,共4页China Journal of Chinese Materia Medica

基　　金：国家中医药管理局青年基金资助项目(97Y013);江苏省高校高新技术产业发展项目(JH02 103)

摘　　要：目的:比较麝香酮(muscone)在β-环糊精、HP β 环糊精分子包合物中以及脂质体载体中的透皮扩散情况。方法:采用Franze扩散池,进行小鼠离体皮肤渗透扩散试验,比较其透皮扩散特征。结果:麝香酮HP-β-环糊精分子包合物以及脂质体后的经皮渗透速率明显大于麝香酮,麝香酮β-环糊精包合物则较低。结论:麝香酮HP-β-环糊精包合或脂质体化后能够促进麝香酮的经皮渗透。Objective: To compare the penetrating rate of muscone in different inclusion complexes and liposome. Method: The transdermal effect of muscone in different inclusion complexes and liposome was studied comparatively on rat skin with 40%EtOH as the absorption solution and with an improved Franz diffuse cell. Result: Among the different inclusion complexes and liposome, the penetrating rate of muscone in the HP-β-cyclodextrin inclusion and the liposome were higher than muscone,and that of muscone in the β-cyclodextrin inclusion is the lowest. Conclosion: the HP-β-cyclodextrin inclusion and the liposome can hence the muscone transdermal speed.

关 键 词：麝香酮 脂质体 包合物 透皮扩散 经皮渗透 β-环糊精 离体皮肤 载体 扩散池 速率 

分 类 号：R283[医药卫生—中药学]