葛根素注射液对急性脑缺血模型大鼠脑细胞损伤的保护作用  

Protection of puerarin on the cerebral injury in the rats with acute local ischemia

作　　者：潘洪平[1] 杨嘉珍[1] 莫祥兰[1] 李吕力[1] 黄振录[1] 叶劲[1] 黄进[1] 

机构地区：[1]广西壮族自治区人民医院,广西南宁530021

出　　处：《中国中药杂志》2005年第6期457-459,共3页China Journal of Chinese Materia Medica

基　　金：广西壮族自治区卫生厅医药卫生科研课题(Z2001072)

摘　　要：目的:探讨葛根素注射液对急性脑缺血模型大鼠脑细胞损伤的保护作用。方法:采用闭夹大脑中动脉造成局部脑缺血模型,对实验标本作HE染色后观察其脑组织的病理学改变。结果:葛根素干预组死亡神经元数明显少于单纯缺血组(P<0.05),同时脑水肿程度明显较轻。结论:葛根素对大鼠急性脑缺血损伤有保护作用。Objective: To study the protection of puerarin on the cerebral injury in the rats with acute local ischemia. Method: Rat model of acute local cerebral ischemia was made by ligating middle cerebral artery. The cerebral damage was evaluated by staining with hematoxylin and eosin((HE). Result: The number of died neurons were significantly less in puerarin-treated rats than in the rats with cerebral ischemia (P<0. 05). Similarly,the cerebral edema were significantly attenuated in the puerarin-treated rats as compared with cerebrally ischemic rats. Conclusion: Puerarin can prevent the neuron from damage induced by acute cerebral ischemia.

关 键 词：保护作用 模型大鼠 急性脑缺血 葛根素注射液 脑细胞 损伤 病理学改变 结论 目的 方法 

分 类 号：R285[医药卫生—中药学]