新型含嘧啶氨基吡唑类化合物的合成及生物活性  

Synthesis and Biological Activity of 3-Pyrimidylamino-pyrazoles

作　　者：邹小毛[1] 吴超[1] 周传政[1] 任雪玲[2] 杨华铮[1] 

机构地区：[1]南开大学元素有机化学国家重点实验室,元素有机化学研究所,天津300071 [2]天津大学化工学院,天津300072

出　　处：《高等学校化学学报》2005年第3期456-460,共5页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金 (批准号 :2 0 172 0 3 1);教育部博士学科点专项基金资助 .

摘　　要：合成了一系列新型含有嘧啶氨基的吡唑类化合物 ,化合物的结构经 1 H NMR及元素分析确证 .生物活性测试表明 ,一些化合物对小麦赤霉、番茄早疫、芦笋茎枯、苹果轮纹以及花生褐斑等病害显示出一定的抑制活性 ,一些化合物具有一定的除草活性 ,还有的化合物对黄瓜子叶生根有一定的促进作用 .实验表明这类化合物结构的变化对活性有重要影响 .It has been reported that pyrazole and pyrimidine heterocyclic compounds maybe exhibit high pharmaceutical functions and pesticidal activity. A series of novel pyrimidylamino-pyrazole derivatives were synthesized and their biological activities were studied. All of the products were confirmed by 1H NMR and elemental analysis, and some of them were characterized by IR and MS. The bioassy results indicated that some of the title compounds have a high fungicidal activity or herbicidal activity. In addition, the structure-activity relationship was discusses.

关 键 词：吡唑衍生物 氨基嘧啶 生物活性 

分 类 号：O626[理学—有机化学]