同型半胱氨酸与2型糖尿病血管并发症的关系  

Relation between homocysteine and angiopathy in type 2 diabetes mellitus

作　　者：何兰杰[1] 刘萍[1] 王金凤[2] 李正直[2] 

机构地区：[1]宁夏医学院附属医院内分泌科,银川750004 [2]宁夏医学院科研处

出　　处：《陕西医学杂志》2005年第3期284-286,共3页Shaanxi Medical Journal

基　　金：宁夏回族自治区自然科学基金项目 (A3 0 2 7

摘　　要：目的 :探讨同型半胱氨酸与糖尿病血管并发症的关系。方法 :1 2 4例糖尿病患者分为三组 :单纯糖尿病组、糖尿病微血管病变组和糖尿病大血管病变组 ;正常对照组 30例 ,测定血浆 Hcy,PAI- 1水平及生化指标。结果 :糖尿病大血管病变 Hcy水平明显高于其他三组 ,糖尿病微血管病变组与对照组无显著性差异。结论 :高同型半胱氨酸血症与 2型糖尿病大血管病变的发病有关 ,与微血管病变无相关性 ,需行维生素 B12 、B6 、叶酸等纠正高 Hcy血症。Objective:To investigate the relatio n between homocysteine(Hcy)and angiopathy in type 2 diabetes mellitus. Methods: 124 NIDDM subjects including simple DM,microangiopathy,macroangiopathy and 30 no rmal subjects were measuried for plasma Hcy,PAI-1,serum biochemical index. Res ults:The patients with macroangiopathy had higher levels and higher prevelance of hyperhomocysteinemia than normal group, while the patients with microangiop athy shoued no significant difference. Conclusions:Fasting homocysteine correla ted with macroangiopathy but not with microangiopathy. VitameB 6, B 12, f olate can correct hyperhomocysteinemia.

关 键 词：同型半胱氨酸 2型糖尿病 糖尿病血管并发症 对照组 糖尿病大血管病变 糖尿病微血管病变 PAI-1 水平 结论 纠正 

分 类 号：R587[医药卫生—内分泌] R541.4[医药卫生—内科学]