竹叶提取物对大鼠血液流变学的影响  

The Effect of Bamboo Leaves Extract on Hemorheology of Normal Rats

作　　者：付晓春[1] 王敏伟[1] 李少鹏[2] 李艳春[1] 

机构地区：[1]沈阳药科大学药学院,沈阳110016 [2]中国医科大学第二临床医院神经外科,沈阳110016

出　　处：《中药材》2005年第2期130-132,共3页Journal of Chinese Medicinal Materials

摘　　要：60只大鼠随机分为 6组,皮下注射异丙肾上腺素,建立血瘀模型,静脉给予不同剂量的竹叶提取物 (15mg/kg、30mg/kg和 60mg/kg),用MVIS 2000全自动血液流变学分析系统测定全血粘度(BV)、血浆粘度 (PV)、纤维蛋白原(FIB)、血细胞比容积(HCT)、血沉(ESR)、血沉方程k(TK)、红细胞电泳时间 (t);小鼠 60只随机分为 6组,静脉给予不同剂量的竹叶提取物(22 .5mg/kg, 45mg/kg, 90mg/kg)后小鼠眼眶静脉采血取血清,测定血清胆固醇。结果表明竹叶提取物能显著降低血瘀模型大鼠全血粘度,降低血浆粘度,降低纤维蛋白原的含量,并能显著降低红细胞比容积,减慢血沉速度,降低血沉方程k值(TK),显著加快红细胞电泳时间;竹叶提取物能明显降低高胆固醇血症小鼠的血清胆固醇。Sixty rats were randomly divides into six groups.Blood stasis model was set up by sc isoprenaline, and different dose of BLE(15 mg/kg,30 mg/kg and 60 mg/kg)were iv.The effects of BLE on rat's blood viscosity, plasma viscosity, FIB, ESR, TK, electrophoresis times and HCT were measured by automatic analysis system. Sixty mice were randomly divided into six groups, and the serum cholesterol of the high cholesterol's mice was obtained by eyepit vein and measured.The results showed that BLE(15 mg/kg, 30 mg/kg and 60 mg/kg)could reduce blood viscosity, plasma viscosity, FIB, ESR, TK, HCT and increase the speed of electrophoresis time in blood adhesion model, and BLE(22.5 mg/kg,45 mg/kg,90 mg/kg)could significantly reduce serum cholesterol of the high cholesterol's mice.

关 键 词：血沉 竹叶提取物 血液流变学 大鼠 小鼠 红细胞电泳时间 不同剂量 血清胆固醇 含量 红细胞比容 

分 类 号：R446[医药卫生—诊断学] R285.5[医药卫生—临床医学]