大川芎方提取物对犬脑血管张力的影响  

The influence of dachuanxiongfang extracts on tension of cerebral vessels

作　　者：汤劐菱[1] 杨芳炬[1] 王正荣[2] 刘之光[3] 李嘉豪[3] 

机构地区：[1]四川大学华西基础医学与法医学院药理学教研室,成都610041 [2]四川大学华西基础医学与法医学院生物医学工程研究室,成都610041 [3]四川大学华西基础医学与法医学院机能学实验室,成都610041

出　　处：《四川生理科学杂志》2004年第1期32-34,共3页Sichuan Journal of Physiological Sciences

摘　　要：目的 :观察大川芎方提取物对犬脑血管张力的影响。方法 :取犬基底动脉制成离体血管段 ,用不去除内皮和去除内皮胰蛋白酶消化法消化两种方法 ,分别给予大川芎方 1 -5号提取物 (均配成 1 0 %浓度 ) ,剂量分别为 0 .6ml、1 .2ml、2 .4ml,同时用川芎嗪注射液进行比较。通过生理记录仪记录给药前后血管张力 ,并计算张力差值。结果 :大川芎方的不同比例配伍药物的提取物 ,均可减少不去除内皮和去除内皮的离体基底动脉血管张力。结论 :大川芎方 1 -5号提取物可明显降低脑血管张力 ,其血管扩张作用可能通过对血管平滑肌的直接作用。Objective: To investigate the influence of dachuanxiongfang extracts on tension of in vitro animal cerebral vessels. Methods:After having isolated sections of blood vessels from basilar artery of dogs. We determined the difference of tension of these sections of vessel series of dachuanxiongfang extracts (No. 1～5)(0.6ml,1.2ml,2.4ml). 0.9%NaCl(0.6ml) and ligustrazine(0.4ml,0.8ml)were added into the perfusate. Were used at control. Then these sections of blood vessel were removed endothelium from the same section by using trypsin. Once again we determined the difference of tension of these sections of vessel. Results: All of these drugs samples could decrease tension of isolated sections of cerebral basilar artery whether with or withont endothelium existed.Conclusion:dachuanxiongfang extracts. number 1 5 can decrease the tension of cerebral vessels distinctly. They may possible expanded vessels through vascular smooth muscle.

关 键 词：大川芎方提取物 脑血管张力 胰蛋白酶消化法 川芎嗪注射液 血管扩张作用 基底动脉 生理记录仪 血管平滑肌 离体血管 配伍药物 不同比例 直接作用 内皮 去除 给药前 

分 类 号：R285[医药卫生—中药学]