小檗碱与硝苯地平治疗原发性高血压的比较  

Berberine vs nifedipine in treating essential hypertension

作　　者：赵海英[1] 毛秀菊[1] 朱会平[1] 张彦通[1] 聂瑞景[1] 

机构地区：[1]河北省复员军人医院

出　　处：《新药与临床》1994年第1期25-26,共2页

摘　　要：原发性高血压７８例，采用小檗碱治疗３８例（男性３６例，女性２例；年龄６４±ｓ５ａ）；剂量０．３－０．６ｇ，ｔｉｄ或ｑｉｄ。另外４０例采用硝苯地平治疗（男性３８例，女性２例；年龄６５±５ａ），剂量１０－２０ｍｇ，ｔｉｄ或ｑｉｄ。２组均以４ｗｋ为一个疗程。结果提示小檗碱对高血压患者的舒张压有降压效果，但疗效远不及常用量之硝苯地平（３４％ｖｓ９０％）（Ｐ＜０．０１），惟不良反应轻微。For oral treatment of essential hypertension 38 patients(M36,F2;age 64±s 5 a) were given berberire 0.3-0.6g,tid or qid×4 wk,and 40 patients(M38,F2;age 65±5 a) were given nifedipine 10-20 mg,tid or qid×4 wk.Results showed that the hypotensive effect of berberine was much weaker than that of nifedipine(34% vs 90%),while the adverse reactions after berberine were light.

关 键 词：小檗碱 硝苯地平 高血压 

分 类 号：R972.4[医药卫生—药品]