地奥心血康对肾性高血压大鼠血流动力学的影响  

Effects of Di-ao-xin-xue-kang on hemodynamics in renovascular hypertensive rats

作　　者：袁恩荣[1] 刘泽[1] 陈建萍[1] 

机构地区：[1]第一军医大学珠江医院,中国科学院成都生物研究所制药厂

出　　处：《新药与临床》1994年第3期147-148,共2页

摘　　要：肾性高血压大鼠（ＲＨＲ）较对照假手术大鼠的ＳＢＰ，ＤＢＰ，ＬＶＥＳＰ，ＬＶＥＤＰ，＋ｄｐ／ｄｔ及｜－ｄＰ／ｄｔ｜值均显著增加（Ｐ均＜０．０１）。应用地奥心血康较用生理盐水对照的ＲＨＲ上述指标分别减少３１．２％，３５．９％，３２．６％，５０．８％，２５．７％和３０．２％（Ｐ均＜０．０１）。心率降低１７．５％（Ｐ＜０．０１）。提示地奥心血康对大鼠心脏具有负性变时、变力作用，可明显改善左心室的舒缩性能。The systolic blood pressure(SBP),diastolic blood pressure(DBP),left ventricular end systolic pressure(LVESP),left ventricular end diastolic pressure(LVEDP) and±dP/dt values on renal hypertensive rats(RHR) were higher than those on sham-operated rats(all P<0.01).SBP.DBP.heart rate(HR),LVESP,LVEDP,+dp/dt and |-dp/dt|on RHR treated with Di-ao-xin-xue-kang(DAXXK) reduced 31.2%,35.9%.17.5%,32.6%,50.8%,25.7%.and 30.2%,respectively compared with those on normal saline-treated group(all P<0.01).The results showed that DAXXK improved left ventricular systolic and diastolic functions and the antihypertensive effect is related to its negativechronotropic and inotropic effect to the heart.

关 键 词：地奥心血康 肾性高血压 血液动力学 

分 类 号：R965.2[医药卫生—药理学]