地奥心血康对大鼠主动脉^（45）Ca内流的影响  

Influence of Di-ao-xin-xue-kang on ^(45)Ca transmembrane influx in rat aorta

作　　者：陈恒留[1] 莫尚武[1] 周懋伦[1] 周正质[1] 陈建萍[1] 刘忠荣[1] 

机构地区：[1]四川大学原子核科学技术研究所,中国科学院成都生物研究所制药厂

出　　处：《新药与临床》1994年第3期144-146,共3页

摘　　要：用^（４５）Ｃａ跨膜流动测定方法研究地奥心血康及维拉帕米对大鼠主动脉Ｃａ^（２＋）跨膜内流的影响。结果：地奥心血康５－５００μｇ／ｍＬ和维拉帕米０．０１１－１．１μｍｏｌ／Ｌ，不影响静息^（４５）Ｃａ的内流，但均能浓度依赖性抑制去甲肾上腺素１．２ｍｏｌ／Ｌ和ＫＣｌ１００ｍｍｏｌ／Ｌ引起的^（４５）Ｃａ内流。说明地奥心血康能阻滞细胞外Ｃａ^（２＋）通过受体操纵与电压依赖钙离子通道的内流。Di-ao-xin-xue-kang(DAXXK) is a Chinese drug for treatment of coronary disease,The influences of DAXXK and calcium channel blockers verapamil(Ver)on ￣(45)Ca transmembrane influx in rat aorta rings were studied.Resting ￣(45)Ca influx was not markedly altered by DAXXK;whereas the ￣(45)Ca influxes evoked by levarterenol(norepinephrine,1.2 μmol/L) and KCl(100 mmol/L) in rat aorta were inhibited by DAXXK 5-500 μg/mL,These characteristics of DAXXK were similar to Ver.The results indicated that extracellular Ca￣(2+) transmembrane influx through receptor-operated Ca￣(2+) channels and potential-dependent Ca￣(2+)channels could be blocked by DAXXK.

关 键 词：地奥心血康 维拉帕米 胸主动脉 

分 类 号：R965.2[医药卫生—药理学]