地奥心血康对心肌缺血再灌注犬心功能及去甲肾上腺素含量的影响  

Effects of Di-ao-xin-xue-kang on cardiac function and serum levarterenol in dog myocardial reperfusion injuty

作　　者：张键[1] 王蔚东[1] 赵丹[1] 刘子红[1] 赵雪俭[1] 

机构地区：[1]白求恩医科大学第一临床学院心血管内科,白求恩医科大学病理生理研究室

出　　处：《新药与临床》1994年第3期130-133,共4页

摘　　要：２８只杂种犬分地奥心血康组（ＤＡＸＸＫ）和生理盐水组（ＮＳ）。结扎冠状动脉左前降支使心肌缺血。分别于结扎即刻静脉滴注ＤＡＸＸＫ（５．０ｍｇ／ｋｇ）和１００ｍｌＮＳ。ＮＳ组随缺血再灌注时间延长，ＣＩ，ＬＶＳＰ，±ｄＰ／ｄｔｍａｘ，等明显下降，而ＴＰＶＲ与血清Ｌｅｖ含量进行性升高。ＤＡＸＸＫ与ＮＳ比较，有显著改善心功能的效应。To determine the effects of Di-ao-xi-xue-kang(DAXXK) on myocurdial reperfusion injury,28 open-chest dogs were subjected to left anterior coronary descending artery occlusion for 90 min followed by 4 h reperfusion.Dogs were randomized to receive either DAXXK(5.0mg/kg,n=10) or saline(NS,n=18) iv at the moment of occlusion.Cardiac function and hemodynamic variables were measured before occlusion,90 min after occlusion,and 30 min,2 h and 4 h after reperfusion.Levarterenol(Lev)in serum was evaluated before occlusion,90 min after occlusion,2h and 4 h after reperfusion. Cardiac indexCI),left ventricular pressusre(LVSP)and ±dp/dt_(max) markedly decreased.while total peripheral vasculaar resistance(TRVR)and Lev in serum were increased with the development of occlusion-reperfusion in NS group.DAXXK improved left ventriculaar function after occlusion-reperfusion in comparison with NS group,and there was a decreasing tendency of TPVR and Lev in DAXXK group.These results suggest that DAXXK reduees myocardial ischemia reperfusion injury with salvage of myocardium,improved cardiac function,and reduced TPVR and Lev as well.

关 键 词：心肌再灌注 损伤 地奥心血康 

分 类 号：R965.2[医药卫生—药理学]