ob基因及其表达产物的生物学效应  

The Bio-Effects of Ob Gene and Its Product Leptin

作　　者：贾善刚[1] 张丽[1] 赵高峰[1] 陈宏[1] 

机构地区：[1]西北农林科技大学动物科技学院陕西省农业分子生物学重点实验室,陕西杨凌712100

出　　处：《黄牛杂志》2005年第2期42-45,共4页Journal of Yellow Cattle Science

基　　金：国家863计划项目(2003AA243051);国家自然科学基金(30471238);河南省杰出人才创新基金资助.

摘　　要：ob基因自从被克隆后,围绕其表达产物的作用机理和生物学效应进行了大量的研究,最近研究证明Leptin对小鼠大脑发育有重要功能,标志着Leptin的研究进入了一个新的阶段,今后将从单一的营养调控研究转向兼顾神经生物学的研究,更深入研究Leptin作用机理。同时国内外学者从分子领域探究ob基因在畜禽育种上的作用,做了很多的工作,也取得了重要的成果。本文总结了ob基因的重要生物学效应,为理解ob基因的作用机制和进一步研究人类肥胖治疗和提高动物生长繁殖性状水平提供必要的支持。After ob gene was cloned, many studies have been involved in mechanism and bio-effects of its product Leptin protein. Recently it was proved that Leptin acts on the growth of mice's brain, which indicates a new stage of the Leptin research focusing on both its neurobiological actions and nutritional regulation, and further studies on mechanism of Leptin. Meantime, scientists had done much work for effects of ob gene and Leptin on animal and poultry breeding and made the great progress. The significant biological effects of ob gene were summarized to provide essential information in understanding the regulation mechanism of ob gene, studying the treatment methods of human obesity and improving animal growth and reproductivity.

关 键 词：生物学效应 治疗 表达产物 OB基因 肥胖 小鼠 研究 动物生长 畜禽育种 繁殖性状 

分 类 号：S813[农业科学—畜牧学] S826[农业科学—畜牧兽医]