盐酸二氢埃托啡和美沙酮联合治疗海洛因瘾  

Dihydroetorphine combined with methadone on heroinism withdrawal

作　　者：沙丽君[1] 刘泽源[1] 张志祥[1] 程琳霞[1] 陈宏[1] 

机构地区：[1]成都军区昆明总医院全军药物依赖康复防治研究所

出　　处：《新药与临床》1994年第6期337-339,共3页

摘　　要：年龄、病程近似的海洛因依赖者８０例，随机分为３组。Ａ组２０例，口服美沙酮７－８ｄ，总剂量１３０－１６０ｍｇ。Ｂ组２０例，静脉滴注二氢埃托啡（ＤＨＥ）３ｄ，ｄ４改舌下含入，总剂量２．６－３．０ｍｇ。Ｃ组４０例，静脉滴注ＤＨＥ３ｄ，总剂量１．２－１．６ｍｇ，ｄ４口服美沙酮３－５ｄ，总剂量６０－１００ｍｇ。结果Ｃ组优于前２组，戒断症状缓解快，用药量少。Eighty patients with heroinomania who were similar in ages and courses were randomly divided into three groups. Group A(n=20)took methadone, po,total 130-160mg for 8 d. Group B(n=20) received dihydroetorphine(DHE)iv drip for 3 d,then SL for 5d, total 2.6-3.0 mg. Group C(n=40)received DHE iv drip for 3d, total 1.2-1.6 mg,then methadone for 5d, total 60-100 mg.Results showed that Group C had quicker effect in eliminating opium abstinence symptoms with lower doses(P<0.01).

关 键 词：二氢埃托啡 美沙酮 海洛因瘾 联合药物疗法 

分 类 号：R163[医药卫生—公共卫生与预防医学] R595.305