作用于RAAS的抗高血压药研究进展  

Recent Progress on Anti-hypertensive Drugs Targeting Renin-angiotensin-aldosterone System

作　　者：张碧玫[1] 余文博[1] 

机构地区：[1]天津医科大学总医院药剂科,天津300052

出　　处：《药学进展》2005年第3期136-141,共6页Progress in Pharmaceutical Sciences

摘　　要：综述作用于肾素 -血管紧张素 -醛固酮系统 (RAAS)的抗高血压药研究进展 ,分别介绍血管紧张素转化酶抑制剂、血管紧张素Ⅱ受体拮抗剂及肾素和醛固酮抑制剂的药理作用、不良反应以及若干目前临床常用或正在研发中的相应药物及其特点。作用于RAAS药物的研发为治疗高血压提供了更多的选择。Recent progress on anti-hypertensive drugs targeting renin-angiotensin-aldosterone system (RAAS) was summarized. The pharmacological actions and adverse effects of angiotensin-converting-enzyme inhibitor, angiotensin Ⅱ receptor antagonist, renin inhibilor and aldosterone inhibitor were described and some of these drugs often used or in development and their properties were introduced. The development of the drugs targeting RAAS offers more choices for treatment of hypertension.

关 键 词：肾素-血管紧张素-醛固酮系统 高血压 血管紧张素转化酶抑制剂 血管紧张素Ⅱ受体拮抗剂 

分 类 号：R972.4[医药卫生—药品]