内皮素和降钙素基因相关肽对异丙肾上腺素致心肌损伤的影响  

The Effect of Endothelin and Calcitonin Gene-Related Peptide on Isoprenaline-induced Damage of Rat Myocardium

作　　者：谭敦勇[1] 张继峰[1] 傅爱华[1] 宋良文[1] 汤健[1] 唐朝枢[1] 

机构地区：[1]北京医科大学心肺内分泌研究室

出　　处：《心肺血管病杂志》1994年第1期43-44,共2页Journal of Cardiovascular and Pulmonary Diseases

摘　　要：本实验在大鼠异丙肾上腺素（ＩＳＯ）心肌损伤模型上，观察了内皮素（ＥＴ）及降钙素基因相关肽（ＣＧＲＰ）对ＩＳＯ损伤心肌作用的影响．结果表明：ＥＴ明显加重ＩＳＯ对心肌的损伤，ＣＧＲＰ则能减轻ＩＳＯ对心肌的损伤及ＩＳＯ与ＥＴ对心肌的协同损伤．提示心肌病理情况下，ＥＴ是一种促损伤因素，而ＣＧＲＰ是抗损伤因素．The effect of endothelin (ET) and calcitonin gene related peptide(CGRP)on the isoprenaline(ISO)-induced damage of rat myocardium was investigated.It was found that administration of ET greatly aggravated,but CGRP alleviated the myocardial damage induced by ISO,and that the aggravating effect of ET was obviously antagonized by infusion of CGRP.The results suggested that CGRP could be available in treating cardio and cerebral-vascular diseases, in which ET is involved.

关 键 词：内皮素 异丙肾上腺素 心肌 CGRP 

分 类 号：R542.2[医药卫生—心血管疾病]