N-烃氧羰基-2-噻唑烷酮衍生物的合成及其杀菌活性(英文)  

Synthesis and Fungicidal Activities of N-Carboalkoxy(aryloxy)-2-thiazolidinones

作　　者：翁建全[1] 沈德隆[1] 陈杰 刘会君[1] 陈庆悟[1] 谭成侠[1] 

机构地区：[1]浙江工业大学化学工程与材料学院,浙江杭州310032 [2]国家南方农药创制中心浙江基地生测部,浙江杭州310023

出　　处：《农药学学报》2005年第1期73-76,共4页Chinese Journal of Pesticide Science

基　　金：Foundationitems:SupportedbytheEducationBureauFoundationofZhejiangProvince(No. 20030145).

摘　　要：为了寻求新的杀菌先导化合物,通过 2 噻唑烷酮与氯甲酸酯的缩合反应得到 11个N 烃氧羰基 2 噻唑烷酮衍生物(5a^5k),其中 10个为新化合物,其结构均经 1HNMR、MS、IR和元素分析表征。初步离体杀菌实验结果表明,大多数化合物较之母体 2 噻唑烷酮具有更高的杀菌活性。在浓度为 2 000 mg/L下,化合物 5c、5d、5e、5f、5g、5h、5i、5j对油菜菌核病菌Sclerotiniasclerotiorum的抑制率为 100%, 5i对番茄灰霉病菌Botrytiscinerea、柑桔青霉病菌Penicilliumitalicum和油菜菌核病菌的抑制率均为 100%。In order to find new fungicidal lead compounds, eleven N-carboalkoxy(aryloxy)-2-(thiazolidinones,) ten of which are novel compounds, were prepared from a condensation reaction of (2-thiazolidinone) and chloroformate, and their structures were confirmed by ^(1)H NMR, MS, IR and (elemental) analysis. The results of fungicidal tests, at the concentration of 2 000 mg/L, indicated that some of them exhibited good activities toward various plant disease fungi. Compounds 5c, 5d, 5e, 5f, 5g, 5h, 5i, 5j showed excellent inhibitory activities (100%) against Sclerotinia sclerotiorum. (Compound) 5i showed excellent inhibitory activities (100%) against Botrytis cinerea, Penicillium (italicum) and S. sclerotiorum, and also showed inhibitory activities against Xanthomonas oryzae, Pseudomonas solanacearum.

关 键 词：N-烃氧羰基-2-噻唑烷酮衍生物 合成 杀菌活性 

分 类 号：O621[理学—有机化学]