中老年女性骨密度相关因素的临床分析  

Clinical analysis of related factors of bone mineral density in females

作　　者：张清学[1] 杨冬梓[1] 王文军[1] 梁晓余 谢梅青[1] 王良岸[1] 邝健全[1] 蒋宁一[3] 洪顺家[1] 郑澄宇[1] 孙艳梅[1] 陈晓丽[1] 古少君[1] 

机构地区：[1]广州中山大学附属第二医院妇产科,510120 [2]广州港湾医院妇产科 [3]广州中山大学附属第二医院核医学科

出　　处：《中国骨质疏松杂志》2005年第1期68-70,111,共4页Chinese Journal of Osteoporosis

基　　金：广东省卫生厅五个一科教兴医工程重点资助项目(1996 2 0 )

摘　　要：目的　分析中老年女性骨密度的相关因素。方法　从 2 0 0 1年 9月至 2 0 0 2年 8月分层随机抽样 10 90名妇女 ,询问病史、体检 ,按 1∶3的比例随机抽样 330名妇女 ,用双能X线骨密度仪测量其骨密度。结果　随着年龄的增大和绝经年限的延长 ,妇女的骨密度逐渐下降 ,其骨密度值与年龄、绝经年限、初潮年龄、月经周期天数、孕、产次、产后哺乳月数、吸烟、喝酒呈显著负相关 (P <0 . 0 5 ) ,与身高、体重、体重指数呈显著正相关 (P <0. 0 5 )。用逐步回归的方法进行分析 ,年龄、绝经后年限、喝骨头汤量可以进入方程。结论　妇女的骨密度在 4 0岁以上逐渐降低 ,年龄越大、绝经年限越长、孕产次越多、产后哺乳时间越长、有吸烟喝酒习惯者 ,其骨密度较低 ;而体重、体重指数越大 ,其骨密度较高。Objective To analyze the related factors of bone mineral density in females. Methods From September 1998 to August 1999, 1090 women completed a questionnaire in a study by stratified sampling. Their histories and results of physical examination were recorded. Bone mineral density (BMD) at lumbar spines and hip were measured by dual energy X-ray absorptiometry (DEXA) in 330 women. Results The BMD of women over 40 years old decreased gradually with increasing age and duration of menopause. In postmenopausal women, there was a negative correlation between the BMD and their age, years after menopause, pregnancies and labors (P<0.05), months of breast-feeding, age of menarch, length of menstrual cycles, amount of drinking bone soup, smoking and alcohol consumption. There was a positive correlation between the BMD and height, body weight, and body mass index (BMI). Stepwise multiple regression analysis indicated that age was the most important factor influencing BMD. Conclusions The BMD of women over 40 years old decreases gradually. It is negatively related to their age, duration of postmenopause, pregnancies or labors, months of breast-feeding, smoking and alcohol consumption. And it is positively related to their height, body weight, and body mass index.

关 键 词：骨密度 相关因素 妇女 年龄 绝经年限 体重指数 喝酒 吸烟 临床分析 中老年女性 

分 类 号：R681[医药卫生—骨科学] R711[医药卫生—外科学]