大黄素对重症急性胰腺炎大鼠腺泡细胞凋亡的影响  

Influence of emodin on pancreatitic acinar cell apoptosis in rats with acute pancreatitis

作　　者：刘牧林[1] 刘瑞林[1] 姜从桥[1] 马良龙[1] 方先业[1] 

机构地区：[1]蚌埠医学院附属医院胃肠外科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2005年第2期112-113,共2页Journal of Bengbu Medical College

基　　金：安徽省教育厅自然科学研究资助项目 ( 2 0 0 2kj2 13 )

摘　　要：目的 :探讨大黄素对重症急性胰腺炎大鼠腺泡细胞凋亡的影响。方法 :SD大鼠 30只 ,随机分为对照组、胰腺炎组和大黄素组 ,5 %牛磺胆酸钠 1ml/kg制作大鼠重症急性胰腺炎模型 ,大黄素组为模型制作完成时及 3h后腹腔内注射大黄素 2 .5mg/kg ,观察 12h后各组大鼠血清淀粉酶、IL 6和腺泡细胞凋亡情况。结果 :大黄素组血清淀粉酶、IL 6值低于胰腺炎组 (P <0 .0 1) ,细胞凋亡指数增加 (P <0 .0 1) ,病理损害减轻。结论 :大黄素促进重症急性胰腺炎大鼠腺泡细胞凋亡 ,减少淀粉酶和IL 6释放 。Objective:To investigate the effect of emodin on apoptosis of pancreatic acinar cells in rats with acute pancreatitis.Methods:Thirty SD rats were randomly divided into control group,acute necrotizing pancreatitis(ANP) group,and emodin group.5% sodium dexycholate was injected into the intrapancreatobiliary duct to establish acute pancreatitis models and emodin was injected intraperitonealy to induce pancreatic acinar cell apoptosis.The changes of serum amylase,interlukin-6 and apoptosis index were observed.Results:The level of serum amylase and interlukin-6 was lower in the emodin group than that in the ANP(P<0.01).Apoptosis index was higher in the emodin group than that in the ANP (P<0.01).Conclusions:Emodin can induce pancreatic acinar cell apoptosis,decrease the level of amylase and interlukin-6,and relieve the hemorrhage and necrosis of pancreas.

关 键 词：胰腺炎 大黄素 凋亡 大鼠 

分 类 号：R657.51[医药卫生—外科学] R975.3[医药卫生—临床医学]