垂体后叶素对离体蟾蜍心脏收缩力的影响  

Effect of pituitrin on myocardiac contractile force in the heart of the toad in vitro

作　　者：张玲[1] 储莉[1] 何丽亚[1] 徐永俊[1] 

机构地区：[1]蚌埠医学院临床医学系,2001级安徽蚌埠233003

出　　处：《蚌埠医学院学报》2005年第2期123-124,共2页Journal of Bengbu Medical College

摘　　要：目的 :探讨垂体后叶素对蟾蜍离体心脏的作用。方法 :斯氏法游离蟾蜍心脏 ,用 1mlRinger液维持蟾蜍心脏的正常活动 ,分别加入含有垂体后叶素 0 .12 5u/ml、0 .2 5u/ml、0 .5u/ml的Ringer液 ,记录心肌收缩力和心率的变化 ;用 0 .2 5u的垂体后叶素诱导心衰后 ,将 0 .0 4mg毛花甙丙加入灌流液中 ,观察其变化。结果 :与给药前比较 ,垂体后叶素可使蟾蜍心脏心肌收缩力降低 (P <0 .0 1) ;毛花甙丙不能对抗其作用。结论 :垂体后叶素可诱发蟾蜍心脏发生心力衰竭 。Objective:To explore the effect of pituitrin on heart contractile in the toad.Methods:Ringers solution was used to maintain the normal action of the heart,then the heart was perfused by Ringer's solution 1 ml containing pituitrin at concentration of 0.125 u/ml,0.25 u/ml,and 0.5 u/ml,and washed before adding the next dosage.The myocardiac contractile force and heart rate were recorded separately after adding each dosage.The other part of this experiment was that the deslanoside was added to the solution when the heart failure model was caused by pituitrin (0.25 u/ml).The parameters were take down.Results:The myocardiac contractile force was reduced by adding pituitrin compared with control(P<0.05).The reduction of myocardiac contractile force was not antagonized by adding deslanoside.Conclusions:The heart failure can be caused by pituitrin and can't be antagonized by deslanoside in toad.

关 键 词：心力衰竭 充血性 垂体后叶素 蟾蜍 毛花甙丙 

分 类 号：R541.61[医药卫生—心血管疾病] Q575.3[医药卫生—内科学]