肺炎衣原体感染与急性心肌梗死的相关性  

Correlation of chlamydia pneumonia infection and acute myocardial infarction.

作　　者：刘大男[1] 何作云[1] 李金生[2] 

机构地区：[1]第三军医大学新桥医院心内科,重庆现在400037 [2]贵阳医学院附属医院心内科

出　　处：《中国综合临床》2005年第4期291-293,共3页Clinical Medicine of China

基　　金：贵州省科学基金资助(黔科合字19991177)

摘　　要：目的探讨肺炎衣原体(Cpn)感染与冠心病心肌梗死的关系。方法测定51例急性心肌梗死(AMI)和42例陈旧性心肌梗死(OMI)患者及31例冠脉造影正常者(NC)的Cpn抗体(CpnIgG、CpnIgM)水平及DAN,同时观测C反应蛋白(CRP)、血脂[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDLC)、高密度脂蛋白胆固醇(HDLC)]变化。结果AMI组CpnIgG、CpnIgM阳性率及水平高于NC组(P<0.05),CpnDNA检测结果与之吻合。校正冠心病危险因素前、后,CpnIgG阳性与AMI均有相关关系(OR=3.653,P=0.025;OR=3.174,P=0.033)。AMI组中Cpn(+)组CRP、TC、TG、LDLC高于同组中Cpn(-)组(均P<0.05),且IgG与CRP、TC、LDLC呈正相关(P<0.05),调整与CRP相关的冠心病危险因素后,IgG与CRP仍呈正相关;OMI组中Cpn(+)组TG明显高于Cpn(-)组(P<0.05),IgG与TG呈正相关。结论Cpn感染与AMI之间存在明显的相关性,与血脂、CRP也存在相关性。Objective To investigate the correlations between Chlamydia pneumoniae (Cpn) infection and acute myocardial infarction(AMI).Methods Specific Cpn antibodies and the DNA were measured in 51 patients with AMI(AMI group),42 patients with old myocardial infarction(OMI group) and 31normal controls (NC group) who had no angiographic evidence of coronaty artery disease by ELISA.The relationships between C-reative protein(CRP),serum lipids and Cpn infection were determined in the three groups.Results The positive rate and level of Cpn IgG and Cpn IgM in AMI group were higher than those in NC group(P<0.05),and the results were compared by Cpn DNA tests.There is a correlation between positive Cpn IgG and AMI(OR=3.653,P=0.025; OR=3.174,P=0.033).Those whose Cpn were positive in the AMI group had significantly higher levels of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C) and CRP than those whose Cpn were negative in the same group(P<0.05).The level of TG in the Cpn positive patients of old myocardial infarction is higher than those whose Cpn were negative.Correlative analyses revealed that the average concentration of IgG antibody to Cpn was positively associated with the levels of CRP,TC and LDL-C in the Cpn positive patients of the AMI group.Conclusion There is a significant correlation between Cpn infection and AMI.Cpn infection is associated with serum lipids and C-reative protein levels.

关 键 词：心肌梗死 肺炎衣原体 C-反应蛋白 血清脂质 

分 类 号：R542.22[医药卫生—心血管疾病]