核素治疗骨转移瘤有效和无效患者的免疫功能分析  

Immunological functions between effective and ineffective patients with bone metastases after therapy of ^(153)Sm-EDTMP

作　　者：李勇[1] 房娜[2] 

机构地区：[1]吉林大学中日联谊医院放射科,吉林长春130033 [2]哈尔滨医科大学第一临床医学院核医学科,黑龙江哈尔滨150001

出　　处：《中国现代医学杂志》2005年第4期571-573,共3页China Journal of Modern Medicine

基　　金：黑龙江省十五攻关课题(GC02C147-01)

摘　　要：目的研究放射性核素153钐-乙二胺四甲基膦酸(153Sm-EDTMP)治疗骨转移瘤后有效与无效患者的免疫功能变化,揭示免疫学指标与患者预后的关系。方法选择经临床确诊的应用放射性核素153Sm-EDTMP治疗的患者59例及正常对照组20例。分别测定各患者治疗前、治疗后3个月及正常对照组T淋巴细胞亚群CD4+、CD8+及肿瘤坏死因子-α(TNF-α)值,并比较有效患者与无效患者各免疫学指标。结果正常对照组和骨转移瘤患者通过t检验发现各免疫学指标均有显著差异(P<0.01)。治疗后有效患者与无效患者之间各指标差异亦显著(P<0.05)。结论骨转移瘤患者免疫功能抑制。153Sm-EDTMP治疗后,免疫功能得到恢复,无效患者免疫功能经治疗后恢复程度低于有效患者。To investigate the influence of 153Sm-EDTMP on the immunological functions in the patients with bone metastases, compare the differrences between the effective and the ineffective patients and reveal the relations between the immunological indexes and prognosis. 59 patients who were diagnosed by clinic were treated with 153Sm-EDTMP. The CD4+, CD8+, TNF-α(tumor necrosis factor-α) were detected before the 153Sm-EDTMP treatment and at the 3rd month after the therapy, as well in 20 controls. The differences of immunological indexes between the effective and the ineffective patients were also compared. The indexes between the patients and controls before therapy were different significantly (P <0.01). After treatment, the indexes of the ineffective patients were differ obviously to those of the effective ones, too (P <0.05). [Conclusion] The immunological functions in the patients with bone metastases were inhibited obviously. Treating with 153Sm-EDTMP can improve their functions to a certain extent. The recover level of the ineffective patients was lower than that of the effective ones.

关 键 词：骨转移瘤 TNF-α T细胞亚群 153SM-EDTMP 

分 类 号：R817[医药卫生—影像医学与核医学]