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机构地区:[1]广州医学院第一附属医院内分泌科,广东广州510120 [2]广州医学院第二附属医院内分泌科,广东广州510260
出 处:《中国现代医学杂志》2005年第4期585-587,共3页China Journal of Modern Medicine
基 金:广东省自然科学基金(000333)
摘 要:目的探讨绝经后妇女血清瘦素水平及其影响因素。方法绝经后妇女85名,按体重指数(BMI)分为两组,正常组BMI<23kg/m2;超重及肥胖组BMI≥23kg/m2。测腰围、臀围、腰臀比、BMI、体脂量、空腹血清瘦素、空腹和2h血糖和胰岛素、总胆固醇及甘油三酯。结果超重及肥胖组血清瘦素水平较体重正常组显著升高(P<0.001);单因素分析显示绝经后妇女血清瘦素水平与体重(r=0.527,P<0.001)、腰围(r=0.436,P<0.001)、臀围(r=0.543,P<0.001)、BMI(r=0.546,P<0.001)和体脂量(r=0.542,P<0.001)均显著相关。多元线性逐步回归分析显示只有臀围是影响瘦素的独立因素(r=0.591,P<0.001)。结论臀围是影响绝经后妇女血清瘦素水平的主要因素。Objective] To investigate the serum leptin level and its related agents in postmenopausal women. To investigate the serum leptin level and its related agents in postmenopausal women. Eighty-five postmenopausal women were divided into two groups by BMI:normal subjects,BMI<23;overweight and obese group,BMI≥23. Waist circumference,hip circumference,waist to hip ratio,body mass index(BMI),body adiposity,fast serum leptin, fast plasma glucose and 2h plasma glucose of OGTT,fast serum insulin and 2h serum insulin of OGTT,total cholesterol and triglyceride were measured. The serum leptin level was significantly higher in overweight and obese group than that in normal subjects. In univariated analyses,leptin level were significantly correlated with weight (r =0.527, P <0.001),waist circumference (r =0.436, P =0.000),hip circumference (r =0.543, P =0.000), BMI (r =0.546, P <0.001) and body adiposity (r =0.542, P <0.001). In multivariate linear stepwise regression analyses, hip circumference is only the factor affecting leptin level (r =0.591, P <0.001). [Conclusion] Hip circumference is independent factor affecting the serum leptin concentration in postmenopausal women.
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