儿童脑室周围白质软化症的MR扩散张量成像研究  

Diffusion tensor MR imaging in pediatric patients with periventricular leukomalacia

作　　者：谢晟[1] 郭雪梅[1] 崔爱国[1] 肖江喜[1] 蒋学祥[1] 

机构地区：[1]北京大学第一医院放射科,100034

出　　处：《中华放射学杂志》2005年第3期325-327,共3页Chinese Journal of Radiology

摘　　要：目的应用MR扩散张量成像对脑室周围白质软化症(PVL)患儿和正常婴幼儿进行比较。方法对15例正常志愿者和15例PVL患儿进行了扩散张量成像扫描,测量双侧内囊后肢、双侧视放射和胼胝体膝部、压部的部分各向异性(FA)值,并对结果进行统计学比较。结果对照组和PVL组的右侧内囊后肢的FA值分别为0682±0399和0555±0087、左侧内囊后肢的FA值分别为0673±0043和0557±0030,右侧和左侧视放射的FA值分别为0437±0675、0429±0052、0351±0051、0339±0064,胼胝体膝部、压部的FA值分别为0696±0579、0756±0454、0564±0080、0586±0100,差异均有统计学意义(P<001)。结论扩散张量成像能提示纤维束的髓鞘化过程的延迟,反映儿童发育中脑白质微观结构的改变,在PVL的随访观察中具有较大的潜力。Objective To compare pediatric patients with periventricular leukomalacia (PVL) with normal children by using diffusion tensor MR imaging. Methods Diffusion tensor images were obtained in 15 pediatric patients with PVL and 15 age-matched normal children. Regions of interest were drawn to measure the fractional anisotropy (FA) in bilateral posterior limb of internal capsule, bilateral optic radiation, genu of corpus callosum, and splenium of corpus callosum. The values of PVL patients and normal children were compared using non-dependent samples T-test. Results The FA values of regions of interest prescribed were significantly lower in PVL patients than in normal children(P<0.01). Conclusion Diffusion tensor imaging may reveal retard of myelination of fiber tracts in PVL patients. It can be a potential tool in evaluating the brain development of children.

关 键 词：PVL 内囊 MR扩散 脑室周围白质软化症 双侧 后肢 扩散张量成像 延迟 扫描 提示 

分 类 号：R445.2[医药卫生—影像医学与核医学]