广西壮族与汉族IL-6基因启动子-634C/G多态性的研究  

Study of interleukin-6 gene promoter region -634C/G polymorphism in the Zhuangs and Hans in Guangxi province China.

作　　者：韦叶生[1] 蓝艳[2] 刘运广[1] 徐群清[1] 李壮[1] 张良[1] 

机构地区：[1]右江民族医学院附属医院临床检验中心,广西533000 [2]右江民族医学院附属医院皮肤科,广西533000

出　　处：《中国优生与遗传杂志》2005年第3期11-12,共2页Chinese Journal of Birth Health & Heredity

基　　金：广西壮族自治区卫生厅课题 (Z2 0 0 40 3 7)

摘　　要：目的　研究白细胞介素 - 6 (IL - 6 )基因启动子 - 6 34C/G多态性在中国广西壮、汉两民族中的分布。方法　应用聚合酶链反应 -限制性片段长度多态性技术检测 1 85名壮族人和 1 98名汉族人的白细胞介素 - 6基因启动子 -6 34C/G多态性 ,比较两组白细胞介素 - 6基因型和等位基因的分布频率。结果　在壮族人中CC、CG和GG基因型分别为 6 9 7%、2 8 7%和 1 6 % ;在汉族人中CC、CG和GG基因型分别为 6 8 2 %、2 9 3%和 2 5 %。两组白细胞介素 - 6基因型的分布频率差异无显著性 (P >(0 0 5 )。结论　壮族与汉族白细胞介素 - 6基因 - 6 34C/G多态性分布频率差异无显著性。Objective: To study the difference between the Chinese Zhuang and Han ethnic groups in Guangxi province in the distribution of interleukin-6 gene promoter region -634C/G polymorphism. Methods: Interleukin-6 gene promoter region -634C/G polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism in Zhuangs(n=185) and Hans(n=198). Results: The frequencies of CC, CG and GG genotypes were found to be 69.7%, 28.7% and 1.6% in the Zhuangs, and 68.2% , 29.3% and 2.5% in the Hans respectively. There was not significant difference in the frequency distribution of interleukin-6 genotype between the Zhuangs and the Hans (P>0.05).Conclusion: There was not significant difference of interleukin-6 gene promoter region -634C/G polymorphism between the Zhuangs and the Hans.

关 键 词：白细胞介素-6 基因 遗传多态性 壮族 汉族 

分 类 号：R392[医药卫生—免疫学]