脑脊液乳酸脱氢酶测定对成人颅内感染诊断的价值  

Study on the Clinical Significance of Measuring Cerebrospinal Fluid LDH Activity in Adults with Intracranial Infection

作　　者：范学文[1] 杨笑[1] 杜彦辉[1] 孔繁元[1] 

机构地区：[1]宁夏医学院附属医院神经内科,银川750004

出　　处：《宁夏医学院学报》2005年第1期23-24,29,共3页Journal of Ningxia Medical College

摘　　要：目的观察成人颅内感染急性期血清和脑脊液(CSF)乳酸脱氢酶(LDH)的改变及其临床意义。方法用酶速率法测定颅内感染患者(发病3～7d内)血清LDH,并行腰穿取CSF检测LDH、白细胞数、蛋白含量等。结果颅内感染组(病毒性脑炎22例,结核性脑膜炎20例,化脓性脑膜炎18例)CSF-LDH均显著高于对照组(P<005);结脑患者最高,化脑次之,病脑最低,但均高于对照组。各组间血清LDH水平差异无统计学意义(P>005),但与对照组比较有显著性差异(P<005)。CSF中LDH与血清LDH无相关性(r=0145,P>005)。结论成人颅内感染急性期存在明显的CSF-LDH增高,且不同病原感染所致CSF-LDH升高的水平均不相同,故检测CSF中LDH有助于颅内感染的早期诊断和鉴别诊断。Objective To observe the changes and clinical significance of serous and cerebrospinal fluid(CSF)LDH in adults with acute intracranial infection. Methods LDH levels in serum and CSF of the adult patients with acute intracranial infection within 3～7 days after the attack onset were measured by using full-automatic biochemical instrument. Results The CSF-LDH level of intracranial infection group (22 cases with viral encephalitis, 20 cases with tuberculosis meningitis and 18 cases with purulent meningitis) were significantly higher than those of normal control group (P<0.05). The CSF-LDH level of tuberculosis meningitis group was the highest, the purulent meningitis group was the next and viral encephalitis showed the lowest. There were no significant differences in serum LDH level among three patients groups (P>0.05),but significant differences between intracranial infection groups and normal control group were found. No correlations of CSF-LDH level with serum LDH (r=0.145, P>0.05) were found. Conclusion The CSF-LDH level of adult patients with acute intracranial infection increases significantly and is a helpful parameter to the diagnosis and the differential diagnosis of intracranial infection at early stage.

关 键 词：颅内感染 乳酸脱氢酶 脑脊液 

分 类 号：R446.14[医药卫生—诊断学]