骨形态发生蛋白-2诱导心肌干细胞定向分化的信号转导机制  

Mechanisms of Signal Transduction in Bone Morphogenetic Protein-2-induced Cardiomyocyte Differentiation of Cardiac Stem Cells

作　　者：王新艳[1] 谭玉珍[1] 

机构地区：[1]复旦大学上海医学院人体解剖与组织胚胎学系,上海市200032

出　　处：《医学分子生物学杂志》2005年第2期111-114,共4页Journal of Medical Molecular Biology

基　　金：国家自然科学基金(No.30470883)~~

摘　　要：骨形态发生蛋白-2(BMP-2)对心肌干细胞(CSCs)的分化起重要作用,其信号通过受体激活并经Smads、p38MAPK和P1-3K等3条信号通路转导,调节多种心肌转录因子的表达,进而诱导CSCs的终末分化。细胞内的BMP-2信号途径与其它信号途径形成网络,调控机制精密而复杂。明确BMP-2在CSCs向心肌分化中的信号转导机制,将为临床应用CSCs治疗心肌梗塞等疾病提供理论基础。Bone morphogenetic protein-2 (BMP-2) plays an important role in the cardiomyocyte differentiation of the cardiac stem cells (CSCs). It regulates expression of many cardiac transcriptional factors and thereby induces the terminal differentiation of CSCs through activation of its receptors and Smads, p38MAPK and PI-3K signaling pathways. The signal network is formed by crosstalking between BMP-2 signaling pathway and other signaling pathways. The regulating mechanisms of the signal network are precise and complicated. Understanding of the mechanism of BMP-2 in differentiation of CSCs helps to provide theoretical basis for the treatment of myocardial infarction with CSCs.

关 键 词：骨形态发生蛋白-2 心肌干细胞 信号转导 

分 类 号：Q257[生物学—细胞生物学] R318[医药卫生—生物医学工程]