持续性脊髓压迫对脊髓损伤程度的影响  

Effect of sustained spinal cord compression on spinal cord injury

作　　者：谭迎春[1] 冯虎[2] 张轶[2] 汤押庚[2] 

机构地区：[1]徐州医学院附属医院神经科,江苏徐州市221002 [2]徐州医学院附属医院创伤科,江苏徐州市221002

出　　处：《中国康复理论与实践》2005年第2期87-88,共2页Chinese Journal of Rehabilitation Theory and Practice

基　　金：江苏省中医药管理局资助项目(No. 9954)。

摘　　要：目的 探讨脊髓损伤(SCI)后脊髓压迫时间对损伤程度的影响。方法 以大脑皮层诱发电位(CSEP)和不同压迫时间为参数,自行设计一种犬的运动—静止压迫型SCI模型,选择T13为损伤中心,压迫脊髓,当 CSEP波幅下降达基础值的 50%时,维持静止压迫。将28只犬随机分为A、B、C、D 4组,A、B、C组脊髓分别受压30 min、90 min和180 min,D组为对照组,观察各组动物的组织病理学、影像学和行为学变化。结果 损伤组脊髓组织学均有损害,MRI显示损害程度随脊髓受压时间的延长逐渐加重( P<0.01);至术后28 d,各损伤组动物后肢功能均有恢复,BBB分级评分法评估组间有显著性差异( P <0.05)。结论 SCI后持续性脊髓压迫能加重损伤程度,应尽早解除脊髓压迫。ObjectiveTo explore the effect of sustained spinal cord compression on spinal cord injury (SCI).MethodsTwenty four dogs underwent sustained spinal cord compression for 30 minutes (group A), 90 minutes (group B) and 180 min (group C) with a device designed by the authors for weight loading spinal compression, and anthor four dogs as the control group (group D) only underwent surgical operation without SCI. Cortex somatosensory evoked potentials (CSEP) were monitored during all the procedure of making model. The changes of pathologic histology, imaging and behavior examination of all animals were observed.ResultsThe lesion degrees gradually increased from group A to group C ( P<0.01), and there was similar outcome in MRI imaging. The behavior improvement in group A was more significantly than that in groups B and C ( P<0.05).ConclusionSustained spinal cord compression aggravates the extent of SCI process, and the decompression must be taken as soon as possible. [

关 键 词：脊髓 脊髓损伤(SCI) 持续性脊髓压迫 脊髓损伤动物模型 

分 类 号：R651.2[医药卫生—外科学]