延髓腹外侧区在电针内关穴抗急性心肌缺血中的作用  

The role of ventrolateral medulla in the treatment of rabbit myocardial ischemia by electroacupuncture at Neiguan point

作　　者：王华[1] 吴绪平[1] 王述菊[1] 王亚文[1] 陈泽斌[1] 

机构地区：[1]湖北中医学院,武汉430061

出　　处：《中华物理医学与康复杂志》2005年第3期149-151,共3页Chinese Journal of Physical Medicine and Rehabilitation

基　　金：国家自然科学基金资助项目(No.30171179)

摘　　要：目的探讨延髓腹外侧区(VLM)在电针内关穴改善家兔急性缺血心肌细胞动作电位影响中的作用。方法在电针内关穴对家兔急性心肌缺血(AMI)保护作用的基础上,进一步观察VLM贴敷纳络酮阻断后电针内关穴对缺血心肌细胞动作电位的影响。结果VLM阻断组分别与假手术组、急性心肌缺血组及VLM假阻断组比较,在各个时段的ST段电位均有明显升高,MAPA、MAPD50、MAPD90均有明显降低,差异有统计学意义(P<0.05)。结论VLM贴敷纳络酮阻断后,电针内关穴治疗家兔AMI时,心电图ST段电位及心肌细胞动作电位MAPA、MAPD50、MAPD90恢复的时程延长,电针内关穴对缺血心肌的保护作用减弱。Objective To study the function of ventrolateral medulla (VLM) in the treatment of rabbit myocardial ischemia by electroacupuncture at Neiguan point. Methods On the basis of the protection of rabbits against acute myocardial ischemia by electroacupuncture at Neiguan point,the action potential of rabbit's ischemic myocardial cell was observed after the VLM was blocked with Naloxone. Results Compared with the sham operation group, acute myocardial ischemia group and sham VLM block group,the ST segment potential remarkably increased and MAPA, MAPD_~50 ,MAPD_~90 significantly decreased in VLM block group. There were statistic significance(P<0.05～~0.01) . Conclusion After the VLM was blocked with Naloxone, the time of recovery in ST segment potential of ECG and action potential of ischemic myocardial cell MAPA, MAPD_~50 and MAPD_~90 was delayed, and the protection role of myocardium against ischemia exerted by electroacupuncture at Neiguan point was weakened.

关 键 词：内关穴 电针 急性心肌缺血 延髓腹外侧区 阻断 动作电位 缺血心肌 结论 时段 肌细胞 

分 类 号：R245[医药卫生—针灸推拿学]