多功能生物撞击机致间接性幼年山羊颞下颌关节创伤模型的组织病理学变化  

Histopathological changes of the model of lamb indirect temporomandibular joint injury induced by multifunctional biological striking

作　　者：刘桂才[1] 刘彦普[1] 刘军[2] 周树夏[1] 

机构地区：[1]解放军第四军医大学口腔医学院颌面外科,陕西省西安市710032 [2]解放军第二军医大学长海医院口腔科,上海市200433

出　　处：《中国临床康复》2005年第10期76-77,共2页Chinese Journal of Clinical Rehabilitation

基　　金：军队"十五"指令性课题(01L075)~~

摘　　要：目的:运用多功能生物撞击机致间接性颞下颌关节(temporomandibularjoint,TMJ)创伤动物模型研究双侧TMJ损伤情况。方法:实验于2002-06/2003-04在解放军第四军医大学口腔医学院颌面外科创伤实验室完成,实验以幼年山羊作为研究对象,以1MPa气压推动0.845kg的圆柱形钢质抛射体对动物进行致伤,伤后3d,1,2,4,12周对双侧关节结构变化进行观察,并与正常关节对照。结果:伤后3d可见关节滑膜撕裂、颞骨和髁突骨质破坏、关节腔内积血,关节盘以及关节附着的断裂等;7d后,关节积血少见。2周后关节内出现明显的破坏性改变,关节腔内有渗出液。伤后1个月,部分动物的一侧关节盘完全破坏,髁突软骨层消失,关节腔内渗出;对侧关节结构紊乱,关节盘及髁突明显变形、不规则等改变。3个月后,多数关节结构基本正常,但关节内的破坏性改变仍然存在,关节内仍有明显的裂隙或囊状改变,软骨组织变薄,关节盘松解,关节腔扩张等。结论:创伤可导致山羊双侧关节结构不可逆性的破坏,使关节内环境发生改变,诱发TMJ疾病的发生;关节积血及关节盘的破坏在创伤性关节病的发病过程中起重要作用。AIM:To investigate the temporomandibular joint(TMJ) injury by establishing the animal model of direct bilateral TMJ injury induced by multifunctional biological striking.METHODS:The experiment was conducted in the Laboratory for Trauma in the Department of Oral and Maxillofacial Surgery,College of Stomatology,Fourth Military Medical University of Chinese PLA from June 2002 to April 2003.The studying subjects were 15 lambs.The lambs were injured by the steel made cylinder projectile of 0.845 kg pushed at 1 MPa,and another 3 animals were as controls.The changes of injured bilateral TMJ structure were observed at 3 days,1,2,4 and 12 weeks to compare with those of the normal controls.RESULTS:At 3 days after injury,the laceration of synovial membrane,the osseous destruction of temporal bone and condylar process,the hemarthrosis of articular cavity,and the break of articular disc and attachment were found in the suffered sides,and hemarthrosis was found less at 7 days.Intraarticular destructive change was obvious,and effusion in articular cavity was found at 2 weeks.At 1 month posttrauma,the completely damaged structure of unilateral articular disc in partial animals was found,besides the loss of cartilage of the condylar process and effusion in articular cavity were also observed.Meanwhile,the disorder structure of joint,obvious deformation and irregularity of articular disc and condylar process were seen in the opposite sides of joint.Three months later,the structure of most joints was nearly normal,but the destructive changes were still found,accompanied by remarkable intraarticular crevice or bladder like change,thinner cartilage tissues,brisement of articular disc,expansion of articular cavity,and so on.CONCLUSION:Trauma of the lamb chin can result in irreversible changes in bilateral TMJ,alter the internal environment of the joints and induce the attack of TMJ.Hemarthrosis and destruction of articular disc play an important role in the pathogenesis of traumatic arthropathy.

关 键 词：创伤和损伤 颞下颌关节 疾病模型 动物 

分 类 号：R496[医药卫生—康复医学]