高压氧疗法对颈椎管狭窄术后脊髓再灌注损伤等并发症的防治效应  

Hyperbaric oxygen therapy for preventing and treating reperfusion injury and other complications of spinal cord after operation of cervical spinal stenosis

作　　者：范少地[1] 罗卓荆[2] 杨卫红[1] 闫自强[1] 武铁[1] 刘小辉[1] 张魁[1] 雷海录[1] 

机构地区：[1]解放军第四五一医院骨科,陕西省西安市710054 [2]解放军第四军医大学西京医院骨科,陕西省西安市710032

出　　处：《中国临床康复》2005年第10期89-91,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:高压氧对于颈椎病等的治疗有良好的疗效,探讨高压氧对椎管狭窄术后脊髓再灌注损伤等并发症的预防及治疗作用并分析其机制。方法:2001-01/2003-12第四军医大学西京医院骨科收治的各种原因导致的颈椎管狭窄患者90例,随机分为对照组,治疗1组及治疗2组,各30例,对照组同常规直接手术,治疗1组术前给予高压氧治疗1周,治疗2组术前及术后3d各给予高压氧治疗1周,其余治疗同对照组。术前及术后1d,7d,1个月,1年进行JOA评分及体感诱发电位(somatosensoryevokedpotential,SEP)等检测。结果:治疗组和对照组术后JOA评分及SEP检测结果与术前比较差异有显著性意义。治疗组术后JOA评分和SEP检测结果与对照组相比差异有显著性意义(t=3.892～8.510,P<0.01)。结论:术前高压氧治疗有助于减轻和预防术后脊髓再灌注损伤及术后脊髓反跳性水肿。AIM:Hyperbaric oxygen has obvious effects in the treatment of cervical syndrome,etc.This paper aims to investigate the effect and the mechanism of hyperbaric oxygen on reperfusion injury and other complications of spinal cord after operation of cervical spinal stenosis.METHODS:From January 2001 to December 2003,90 patients with cervical spinal stenosis due to various causes who were hospitalized in the Department of Orthopaedics,Xijing Hospital,Fourth Military Medical University of Chinese PLA were randomly divided into treatment group 1,treatment group 2 and control group.Each group had 30 cases.Patients in the control group were performed with direct conventional operation.Patients in the treatment group 1 received hyperbaric oxygen before operation for 1 week.Patients in the treatment group 2 received hyperbarci oxygen before operation for 1 week and after operation for 1 week.Other operative methods were the same as in the control group.JOA scores and somatosensory evoked potential(SEP) in all the cases were evaluated before operation,and 1,7 days,1 month,1 year after operation. RESULTS:There were significant differences in the JOA scores and SEP results in the two groups before and after treatment. The JOA scores and SEP results after treatment in the treatment group were significantly different from those in the control group(t=3.892 to 8.510,P< 0.01).CONCLUSION:Preoperative hyperbaric oxygen therapy can lessen and prevent the postoperative reperfusion injury and rebound edema of spinal cord.

关 键 词：椎管狭窄 高压氧 再灌注损伤 

分 类 号：R641[医药卫生—外科学]