青少年特发性脊柱侧凸的骨密度变化及与血清白细胞介素6浓度的关系(英文)  

Changes of bone mineral density in association with serum interleukin-6 in adolescent idiopathic scoliosis

作　　者：吴洁[1] 邱勇[1] 张乐[1] 孙燕芳[1] 陈新[1] 

机构地区：[1]南京大学医学院附属鼓楼医院,江苏省南京市210008

出　　处：《中国临床康复》2005年第10期223-225,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：背景:青少年特发性脊柱侧凸的骨代谢方面的研究日益受到重视,该类患者存在着低骨量及骨质疏松症,而细胞因子白细胞介素6(IL-6)参与骨代谢的调节,是强有力的骨吸收因子。目的:探讨特发性脊柱侧凸的骨密度变化及与血清IL-6含量的相关关系。设计:以患者及健康志愿者为研究对象,非随机化同期对照研究。单位:一所大学医院脊柱外科。对象:2003-07/10南京大学医学院附属鼓楼医院脊柱外科门诊或病房收治的特发性脊柱侧凸患者36例,男6例,女30例,年龄12～18岁,Cobb角34°～109°,且均为胸弯者;健康青少年志愿者36例为对照,男7例,女29例,年龄13～18岁。方法:应用双能X射线骨密度吸收仪分别对所有研究对象L2～L4和股骨近端(股骨颈、大转子、Ward's三角)的骨密度进行测量,并用酶联免疫吸附试验检测血清中IL-6水平。主要观察指标:①两组腰椎和股骨骨密度比较。②血清中IL-6浓度比较。结果:特发性脊柱侧凸患者的L2～L4和股骨颈、大转子、ward's角的骨密度分别为(0.79±0.12),(0.78±0.12),(0.65±0.10)和(0.69±0.13)g/cm2,均明显低于正常对照组犤(1.09±0.11),(0.95±0.11),(0.78±0.10)和(0.88±0.11)g/cm2犦(P<0.001),血清IL-6水平与正常对照组相比明显升高(P<0.005)。BACKGROUND:There has been increasing attention in the study of adolescent idiopathic scoliosis(AIS)and bone metabolism,which is accompanied by osteopenia and osteoporosis.Interleukin(IL) 6,a cytokine that strongly promotes bone resorption,participates in the regulation of bone metablism. OBJECTIVE:To explore the relationship between changes of bone mineral density(BMD) and serum IL 6 content in AIS. DESIGN:A controlled non randomized concurrent study involving patients with AIS and and healthy volunteers. SETTING:The clinic and wards of the department of spinal surgery of a university affiliated hospital.PARTICIPANTS:Thirty six patients with AIS(6 males and 30 females aged 12 to 18 years) were treated in the Department of Spinal Surgery,Drum Tower Hospital,Medical College of Nanjing University from July to October 2003,who had a Cobb angle ranging from 34° - 109° and curvature of the thoracic spine.Thirty six healthy adolescent volunteers(7 males and 29 females within the range of 13- 18 years old) served as the control group. METHODS:The BMD was measured at L2- L4 and the proximal femur;(including the femoral neck,greater trochanter and Ward's triangle) by dual energy X ray absorptiometry and serum IL 6 determined by enzyme linked immunosorbent assay(ELISA). MAIN OUTCOME MEASURES: ① BMD of the lumbar spine and femur ② Comparison of serum IL 6 content of all the subjects. RESULTS: The BMD of AIS patients at L2- L4,femoral neck, greater trochanter and Ward's triangle was 0.79± 0.12,0.78± 0.12,0.65 ± 0.10,and 0.69± 0.13 g/cm2,respectively,all significantly lower than the corresponding measurements of the control group(1.09± 0.11,0.95± 0.11,0.78± 0.10,and 0.88± 0.11 g/cm2,respectively,P< 0.001),whereas the serum IL 6 content in the patients was significantly higher than that in the control subjects (P< 0.005).The changes of BMD at the lumbar spine and the three sites of femur were negatively correlated with serum IL 6 in AIS patients(P< 0.001),but not so in the control

关 键 词：脊柱侧凸 骨密度 白细胞介素6 

分 类 号：R682.3[医药卫生—骨科学]