骨组织工程支架及相关问题的研究(英文)  

Scaffold materials and related problems in bone tissue engineering

作　　者：华锦明[1] 蔡丽君[1] 

机构地区：[1]苏州大学附属第二医院骨科,江苏省苏州市215004

出　　处：《中国临床康复》2005年第10期254-256,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:自体骨移植在骨外科临床应用范围广泛,存在的问题是自体供骨量严重不足,无法满足各类型较大的骨缺损。组织工程学可以实现骨的再生,为临床骨缺损的修复提供新的方法与途径。回顾近年骨组织工程学研究的进展和其近几年的研究成果,以利于骨组织工程学的深入研究。资料来源:应用网络www.google.com,Medline检索近3年内中国医学核心期刊,以及1964-01/2002-12间关于骨组织工程学研究方面的相关文献,逐一校对,检索词:骨组织工程学(bonetissueengneering),支架(scaffold),羟基磷灰石复合材料(hydroxyapatiecomposits)。资料选择:选择骨组织体外培养、非晶体医用生物复合材料、骨组织工程学研究的进展、骨组织工程学研究成果的实验研究与在骨外科的临床应用等相关文献56篇。数据提炼:在56篇文献中,内容呈不同程度重复的有14篇,给予删除;对42篇文献进行分类整理,用于综述,其中21篇选用为参考文献。资料综合:骨组织缺损后,通常用自体骨移植的方法加以修复,移植替代物有同种异体或异体松质骨或皮质骨、关节、脱钙骨基质、骨髓,另有陶瓷及其复合移植物等;但是对长骨干的大块骨缺损、骨肿瘤大块切除或关节切除后同种、异种骨与关节的重建或修复的研究仍不很理想,尤其对骨组织与神经、肌腱。OBJECTIVE￡o Autologous bone transplantation has been extensively used clinically,but the scant bone source eligible for transplantation cannot meet the demand in large bone defect repair.Tissue engineering seems to provide a way out, by inducing bone regeneration for repairing bone defect.In this article, the authors review the development in bone tissue engineering achieved in recent years. DATA SOURCES￡o A literature review was conducted with Google and Medlinea2 based search for reports published in Chinese on bone tissue engineering in the last 3 years,as well as for worldwide literature published from January 1964 to December 2002,using the key words for retrieval of bone tissue engineering, scaffold, hydroxyapatite composites. STUDY SELECTION:Fiftya2 six articles were selected,which documented in vtiro bone culture,nona2 crystal medical biomaterials,development of bone tissue engineering,experimental and clinical trials of bone tissue engineering and clinical application of the results of bone tissue engineering.DATA EXTRACTION￡o From the 56 articles,14 were excluded for repetition of contents. The remaining 42 were classified for reviewing and 21 of these were enrolled as references here.DATA SYSTHESIS￡o Autologous bone grafting is the usual choice for bone defect repair.The grafts include allografts and xenograft of spongy bone and compact bone,joints,decalcified bone matrix, marrow, ceramics and ceramics composites.But the effect of repair or reconstruction of large bone defect as left by excision of large bone tumors is not satisfactory.Tissuea2 engineering studies on composites for repair of the damaged nerve,tendon and skin are still in their infancy,while studies of bone scaffold materials has made great progress. CONCLUSION￡o Great breakthroughs have been made in tissue engineering and relevant studies of tissue defect and function impairment is fast developing.As the structure of motor system and skeletal system are relatively simple,and the bone or cartilage defects clinically common,bo

关 键 词：生物医学工程 支架 羟基磷灰石类 

分 类 号：R318[医药卫生—生物医学工程]