应用PCR-SSP方法研究越南中部京族HLA-DQA1等位基因的多态性  

HLA-DQA1 genotyping by PCR-SSP technique in Jing nationality of Central Vietnam

作　　者：陈亭平[1] 王琳琳[1] 林伟雄[1] 陈剑峰[1] 谢湘芝[1] 

机构地区：[1]广西医科大学第一附属医院儿科,南宁530021

出　　处：《中国免疫学杂志》2005年第3期198-200,204,共4页Chinese Journal of Immunology

摘　　要：目的检测越南中部京族HLADQA1等位基因的多态性。方法应用PCRSSP方法对105名健康,无血缘关系的越南中部京族儿童、青年进行HLADQA1分型。结果检出10个HLADQA1等位基因,频率最高为DQA10104(213%)和最低为DQA10601(15%)。结论结果表明越南中部京族人的HLADQA1等位基因分布与中国各民族的HLADQA1等位基因分布有差异。Objective:To investigate the polymorphism of HLA-DQA1 genes in Jing nationality of Central Vietnam.Methods:Applied PCR-SSP tecnique to determine the polymorphism of the HLA-DQA1 alleles of 105 healthy children and youth,unrelated individuals in Central of Vietnam.Results:10 HLA-DQA1 alleles were detected of which DQA1*0104 were the most common allele with frequency of 21.3% and lowest frequency is DQA1*0601.Conclusion:The results indicate that HLA-DQA1 alleles polymorphism of Jing nationality in Central Vietnam is different from the other Chinese. [

关 键 词：人类白细胞抗原 HLA-DQA1 PCR-SSP 越南京族 

分 类 号：R392.2[医药卫生—免疫学]