抗早2号方治疗女童真性性早熟150例临床观察  

Clinical Study on the Treatment of Girl GnRH Dependent Sexual Precocity with“Kangzao-Ⅱ Decoction”

作　　者：赵鋆[1] 虞坚尔[2] 朱敏华[1] 曹潇[1] 

机构地区：[1]上海中医药大学附属曙光医院,上海200021 [2]上海市中医医院,上海200071

出　　处：《上海中医药大学学报》2005年第1期15-17,共3页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：上海市卫生局基金资助项目(00416)。

摘　　要：目的观察抗早2号方治疗女童真性性早熟的疗效,并探讨其作用机制。方法150例性早熟女童随机分为治疗组和对照组各75例,分别用抗早2号方和知柏地黄汤治疗,并观察患儿临床症状、体征、疗效,测定促卵泡生成素(FSH)、促黄体生成素(LH)、雌二醇(E2)及子宫卵巢容积、骨龄的变化。结果治疗3个月后,治疗组和对照组总有效率分别达到84·0%和66·7%,两组比较有差异(P<0·05)。治疗组治疗后LH降低,与对照组比较差异显著(P<0·01)。B超显示:治疗组治疗后子宫容积和卵巢容积均明显小于对照组(P<0·01)。用药后6个月骨龄显示:治疗组骨龄增长明显落后于年龄增长,减缓骨龄增长速度优于对照组(P<0·01)。结论抗早2号方治疗女童真性性早熟的疗效确切。Objective To observe the therapeutic effects of “Kangzao-Ⅱ Decoction” in treating girl gonadotropin-releasing hormone (GnRH) dependent sexual precocity and to explore its mechanism.Methods One hundred and fifty subjects were randomized into two groups:treatment group in which 75 girls were treated with “Kangzao-Ⅱ Decoction” and control group in which another 75 girls were treated with “Zhibai Dihuang Decoction”;the clinical effects and changes of FSH,LH,E_2,volume of uterus and ovary and skeletal age were observed.Results After 3-month treatment,the total effective rate was 84.0% in treatment group and 66.7% in control group,with a great difference between them( P <0.05);LH decreased obviously in treatment group( P <0.01);B-ultrasonographic examination showered that the volumes of uterus and ovary in treatment group were smaller than in control group( P <0.01);the skeletal age increase was singificantly behind the age increase,with a lower skeletal age increase speed in treatment group than in control group after 6-month treatment ( P <0.01) .Conclusion“Kangzao-Ⅱ Decoction” has positive effects on GnRH dependent sexual precocity.

关 键 词：女童真性性早熟 抗早2号方 促卵泡生成素 促黄体生成素 雌二醇 子宫卵巢容积 骨龄 

分 类 号：R272[医药卫生—中医儿科学]