乙型肝炎病毒前S1抗原的检测及其临床意义  

Pre-Sl Ag of Hepatitis B Virus: Its Determination and Clinical Significance

作　　者：樊有龙[1] 王外梅[1] 李华[1] 

机构地区：[1]江西医学院第二附属医院,江西南昌330006

出　　处：《中华医院感染学杂志》2005年第3期292-294,共3页Chinese Journal of Nosocomiology

摘　　要：目的探讨乙型肝炎病毒前S1抗原(PreS1Ag)在临床上的应用价值。方法 采用酶联免疫吸附试验 (ELISA)和聚合酶链反应(PCR)方法,对319例乙型病毒性肝炎(以下简称乙肝)患者和30例健康人分别检测 HBV标志、PreS1抗原和乙肝病毒-脱氧核糖核酸(HBV-DNA)。结果 319例乙型肝炎患者中PreS1抗原和 HBV-DNA的检出率分别为51.7％和56.1％,两种方法符合率为92.1％;PreS1Ag在HBeAg阳性(1／3／5) 和HBeAg阴性(1／4／5)中的阳性率分别为88.4％、31.1％,HBV-DNA在HBeAg阳性(1／3／5)和HBeAg阴性 (1／4／5)中的阳性率分别为91.1％、34.1％,HBV-DNA检出率稍高于PreS1抗原的检出率,但两者的检出率差异 无显著性(P>0.05)。结论乙肝病毒PreS1抗原与HBeAg阳性、HBV-DNA阳性呈高度相关,PreS1抗原可与 HBeAg、HBV-DNA同时作为HBV存在复制和传染性的重要检测指标。OBJECTIVE To investigate the clinical significance of pre-S1Ag of hepatitis B virus(HBV). METHODS The markers, pre-S1Ag and DNA of HBV were determined by ELISA and PCR in 319 patients with hepatitis B and 30 healthy persons. RESULTS The positive rates of Pre-S1Ag and HBV-DNA in all patients were 54. 9% and 59. 6%, the two rates were 88. 4% and 91. 1% in patients with HBsAg, HBeAg and HBcAb, and were 31. 1% and 34.1% in patients with hepatitis B (P>0. 05). CONCLUSIONS Pre-SlAg of HBV is highly related to HBeAg and HBV-DNA. They all could use as markers for HBV infection.

关 键 词：乙型病毒性肝炎 乙型肝炎病毒-DNA 乙型肝炎病毒前S1抗原 

分 类 号：R512.62[医药卫生—内科学]