A CLINICAL STUDY ON PROSTATE CANCER DIAGNOSIS WITH cDNA MACROARRAY  

作　　者：钟惟德 刘良式 刘文华 江福能 曾广翘 戴奇山 何慧婵 毕学成 彭志强 谢克基 魏鸿霭 

机构地区：[1]Department of Urology, the First Municipal People’s Hospital, Guangzhou Medical College, Guangzhou 510180 [2]Institute for Life Sciences, Sun Yat-Sen University, Guangzhou 510060

出　　处：《Chinese Journal of Cancer Research》2005年第1期66-70,共5页中国癌症研究（英文版）

摘　　要：Objective: To diagnose prostatic cancer (CaP) with cDNA macroarray. Methods: Total RNA was isolated from patients with prostate cancer and from normal people, and poly(A) RNA was further purified. Then differentially expressed genes were analysed in CaP and normal prostate by cDNA macroarray system. Results: There were differential expressions of nine prostate-associated specific genes in CaP as compared with normal prostate, among which, 7 were significantly up-regulated and 2 were down-regulated. Conclusion: As a diagnostic approach at molecular level, the cDNA macroarray is supposed to elevate the detection rate of CaP.Objective: To diagnose prostatic cancer (CaP) with cDNA macroarray. Methods: Total RNA was isolated from patients with prostate cancer and from normal people, and poly(A) RNA was further purified. Then differentially expressed genes were analysed in CaP and normal prostate by cDNA macroarray system. Results: There were differential expressions of nine prostate-associated specific genes in CaP as compared with normal prostate, among which, 7 were significantly up-regulated and 2 were down-regulated. Conclusion: As a diagnostic approach at molecular level, the cDNA macroarray is supposed to elevate the detection rate of CaP.

关 键 词：PROSTATE NEOPLASM cDNA macroarray 

分 类 号：R737.25[医药卫生—肿瘤]