激素对阿霉素肾硬化大鼠硬化进展的研究  

Effects of glucocorticoid on progress of adriamycin-induced glomerulosclerosis in rats

作　　者：王太华[1] 于克波[1] 李清初[1] 孙芳[1] 马秀萍[1] 

机构地区：[1]泰山医学院附属医院肾内科,山东泰安271000

出　　处：《泰山医学院学报》2004年第6期612-615,共4页Journal of Taishan Medical College

摘　　要：目的　研究糖皮质激素对慢性肾小球疾病肾硬化进展的作用。方法　使用病理、免疫组化和肾功能检测方法。结果　与未用药的硬化组比较 ,地塞米松 (DEX)用药组肾小球基底膜增厚减轻 ;节段硬化、球囊增厚和间质炎性细胞的浸润明显减轻 ;胶原Ⅲ、Ⅳ在病变区域的积聚显著减少 ,肾功能得到不同程度的改善。结论　DEX抑制胶原Ⅲ、Ⅳ在病变区域的增殖 ,可能有延缓肾小球硬化进展和改善肾功能的作用。Objective: To study the effects of glucocorticoid on glomerulosclerosis of chronic glomerulonephritis. Methods: Pathology,immunohistochemistry and renal function were used. Results: Compared with the glomerulosclerosis group,in DEX group the thickening of glomerular basement membrane,segmental glomerulosclerosis,thickening of saccule and the infiltration of the interstitial inflammatory cells are all obviously alleviated. The accumulation of type Ⅲ and Ⅳ collagens in the lesions decreased remarkably .Renal function was improved to various degrees. Conclusion: Dex inhibited the accumulation of type Ⅲ and Ⅳ collagens in the glomerulosclerosis lesions and probably delayed the progress of glomerulosclerosis,then improved the renal function.

关 键 词：糖皮质激素 肾小球硬化 胶原 

分 类 号：R96[医药卫生—药理学]