高血压病患者血压各参数与其发生冠心病脑卒中的相关性研究  

Relationship between parameters of blood pressure and incidence of coronary artery disease or stroke in hypertension patients

作　　者：吴汉宁[1] 孟秋云[1] 徐林[1] 张雪岩[1] 李桂英[1] 陈燕[1] 

机构地区：[1]泰安铁路医院,山东泰安271000

出　　处：《泰山医学院学报》2004年第6期622-624,共3页Journal of Taishan Medical College

摘　　要：目的　探讨高血压病患者血压各参数与其发生冠心病脑卒中的关系。方法　回顾性分析 1190例高血压病患者 ,年龄 4 5～ 6 5岁 ,其中单纯高血压病患者 4 0 0例 ,高血压并发冠心病者 392例 ,高血压并发脑卒中者 398例 ,分析三组患者的血压各参数关系 ,探讨收缩压、舒张压、平均血压、脉压与高血压并发冠心病、脑卒中的相关性。结果　脑卒中组的收缩压显著高于单纯高血压组或冠心病组 (P <0 . 0 5 ) ;冠心病组的舒张压显著低于单纯高血压组或脑卒中组 (P <0 . 0 1) ;脑卒中组的平均血压显著高于单纯高血压组或冠心病组 (P <0 .0 5 ) ;冠心病组或脑卒中组的脉压显著高于单纯高血压组 (P <0 . 0 1)。Logistic回归分析显示 :校正年龄、性别、高血压病程和其他危险因素 (吸烟、糖尿病、高脂血症 ) ,脉压仍与冠心病、脑卒中的发生有显著相关性 (P<0 . 0 5 ,P<0 . 0 1)。结论　中老年高血压病患者 ,收缩压、平均血压与脑卒中的发生有显著相关性 ,舒张压与冠心病的发生有显著相关性 ,脉压与冠心病、脑卒中的发生均有显著相关性。校正年龄、性别、高血压病程和其他危险因素 (吸烟、糖尿病、高脂血症 ) ,脉压是高血压并发冠心病、脑卒中的独立危险因素。Objective: To determine the relationship between parameters of blood pressure and incidence of coronary artery disease (CAD) or stroke in hypertension patients. Methods: 1190 cases aged 45 to 65 with ptimary hypertension were analyzed retrospectively. Simple hypertension patients were 400, incidence of CAD in hypertension patients were 392, incidence of stroke in hypertension patients were 398. Parameters of blood pressure were analyzed in all patients in order to study the relationship between systolic pressure, diastolic pressure, mean blood pressure,pulse pressure (PP) and incidence of CAD or stroke in hypertension patients. Results: There was significant difference of systolic pressure (P<0.05) between patients with stroke and patients with simple hypertension or CAD.There was significant difference of diastolic pressure (P<0.01) between patients with CAD and patients with simple hypertension or stroke.There was significant difference of mean blood pressure (P<0.05) between patients with stroke and patients with simple hypertension or CAD . There was significant difference between patients with CAD or stroke and patients with simple hypertension on PP (P<0.01). Logistic regression analysis showed that PP was still positively related with the incidence of CAD and stroke in essential hypertension patients after sex, age, duration of hypertension and incidence of other dangerous factors (smoking, diabetes, hyperlipemia) were adjusted(P<0.05, P<0.01). Conclusion: In middle-aged and elderly patients with hypertension, systolic pressure and mean blood pressure may be the positive risk factor for stroke in patient with essential hypertension. Diastolic pressure may be positive risk factor for CAD in patient with essential hypertension. PP may be important risk factor for CAD and stroke in patient with essential hypertension. Adjusted by sex, age, duration of hypertension and incidence of other risk factors (smoking, diabetes, hyperlipemia),PP may be an independent and important risk factor for CAD and stroke i

关 键 词：高血压 血压参数 冠状动脉疾病 脑血管意外 

分 类 号：R544.1[医药卫生—心血管疾病]