男性甲亢患者药物治疗后血清免疫缓解指标的探讨  

The Study of Serum Markers of Immunological Remission in Male Hyperthyroidism Patients After Treatment

作　　者：宋庆璋[1] 张爱华[1] 白振莲[1] 卓连坤[1] 王虹[1] 

机构地区：[1]山东省莱芜市人民医院检验科,山东莱芜271100

出　　处：《标记免疫分析与临床》2005年第1期10-12,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：为了探讨男性甲亢患者药物治疗后缓解较慢的原因,通过用放免法测定患者血清β2 MG,TGAb、TMAb的含量变化。将164例男性甲亢患者根据治疗过程分为三组, 即初发组(B组,65),未缓解组(C组,52),缓解组(D组,47);58名正常人作为对照组(A组)。结果显示: 甲亢 B组与 C组血清β2 MG、FT3、FT4 水平明显高于A组(P<0.01),而TGAb、TMAb的阳性率明显下降(P<0.01),B组与 C组 FT3、FT4 与β2 MG呈明显正相关, 而缓解组β2 MG、FT3、FT4 与A组相比, 差别无显著性(P>0.05),D组与 C组相比, TGAb、TMAb阳性率差别无显著性(P>0.05)。D组19.1%的患者血清β2 MG仍明显增高, 23.4%的患者 TGAb、TMAb仍持续阳性。结果提示: 血清β2 MG、TGAb、TMAb可作为男性甲亢免疫缓解指标, 其检测值可以观察疗效, 指导治疗。大约20%左右男性甲亢患者缓解较慢, 可能是由于患者血清β2 MG持续增高, TGAb、TMAb持续阳性造成的。To study the cause for slow recovery in male hyperthyroidism patients after treated with ATD, the changes of serum β 2-MG, TGAb and TMAb were measured by RIA.A total of 164 male hyperthyoidism patients were divided into 3 groups by their different therapeutic effects: untreated patients(group B, n=65), treated but unrelieved patients (group C,n=52), treated and recovered patients(group D,n=47) and 58 normal persons serving as controls (group A).The results indicated that the levels of serum β 2-MG, FT 3 and FT 4 were significantly higher in group B and C than those in group A(P<0.01),but the positive rates of TGAb and TMAb were notably lower than those in group A (P<0.01).There was a positive correlation between FT 3 or FT 4 and β 2-MG respectively in group B and C.There was no significant difference in β 2-MG, FT 3 and FT 4 between group D and A(P>0.05).And there was no diffe- rence in the positive rates of TGAb and TMAb between group D and C(P>0.05).The serum β 2-MG was still higher in 19.1% patients and the positive rates of TGAb and TMAb were also higher in 23.4% patients.These results suggest that β 2-MG,TGAb and TMAb could act as serum markers of immunological remission for male hyperthyroidism patients and the determination of β 2-MG, TGAb and TMAb could be benifical to monitoring therapeutic effect.The cause for slow recovery in about 20% male hyperthyroidism patients might be due to higher serum β 2-MG and higher positive rates of TGAb and TMAb.

关 键 词：男性 甲亢 Β2微球蛋白 甲状腺球蛋白抗体 甲状腺微粒体抗体 放射免疫分析 

分 类 号：R581.1[医药卫生—内分泌]