应用多普勒组织成像技术评价原发性高血压左室舒张功能及其相关因素  

The correlation between left ventricular diastolic function and atrial natriuretic peptide, brain natriuretic peptide in primary hypertension

作　　者：方永奇[1] 孙红丽 张梅[3] 

机构地区：[1]泰山医学院天外村校区病理生理教研室,山东泰安271000 [2]泰山医学院校医院 [3]山东大学齐鲁医院心内科

出　　处：《临床心血管病杂志》2005年第3期136-138,共3页Journal of Clinical Cardiology

摘　　要：目的:应用多普勒组织成像技术(DTI)探讨原发性高血压(EH)左室舒张功能的特点,同时检测血中心钠素(ANP)、脑钠素(BNP)的变化,分析两者与左室舒张功能的关系。方法:对照组20例,EH患者(EH组)61例,均行常规超声及DTI检查,EH患者根据左室质量指数(LVMI)分为左室心肌肥厚(LVH)亚组和无 LVH(NLVH )亚组。DTI测量二尖瓣侧环心肌舒张早期峰值运动速度(e)、晚期峰值运动速度(a)及其比值(e/a),测量二尖瓣瓣尖水平舒张早期的最大流速(E0)、舒张晚期的最大流速(A)及 E0 与A流速的比值E0/A。入选病例均测定血浆ANP、BNP浓度。结果:与对照组相比,EH患者E0/A、e/a减小,LVH亚组减小更明显;与对照组相比,EH血浆 ANP、BNP浓度升高, LVH升高更明显; E0/A、e/a比值与 ANP 呈负相关( r = - 0.56和 r = -0.60, 均P<0.01),与BNP呈负相关( r=-0.62和 r=-0.65,均 P<0.01)。结论:血浆 ANP、BNP与应用DTI技术评价的EH左室舒张功能均有较好相关性。Objective:①To detect the character of left ventricular diastolic function in patients with hypertension by echocardiography;②To analyse the correlation between ANP、BNP and left ventricular diastolic function. Method:Conventional echocardiography and DTI were performed in 61 patients with hypertension and 20 controls. These patients were divided into LVH group and NLVH group by LVMI. DTI indices included e、a、e/a. The plasma levels of ANP and BNP were measured by radio-immunology analysis in all subjects. Result:Compared with control group, E/A、e/a ratio decreased significantly in the hypertension group while ANP, BNP increasedsignificantly in the hypertension group; significant correlation were found between ANP and E 0/A, e/a (r=- 0.56 and r=- 0.60, both P< 0.01) and also were found between BNP and E 0/A, e/a(r=- 0.62 and r=- 0.65, both P< 0.01). Conclusion:ANP、 BNP all had good interrelation with left ventricular diastolic function.

关 键 词：高血压 心室功能 左:心纳素 脑钠素 超声心动描记术 多普勒 

分 类 号：R544.1[医药卫生—心血管疾病]