α_1受体对不同时相心肌线粒体的影响  

The effect of α_1 adrenoceptor for mitochodria morphology in the different blood supply states

作　　者：方宏 冯义柏[1] 方盈 

机构地区：[1]华中科技大学协和医院心导管室华中科技大学同济医学院心血管病研究所

出　　处：《临床心血管病杂志》2005年第3期179-181,共3页Journal of Clinical Cardiology

摘　　要：目的:研究α1 受体的活化与不同时相心肌线粒体的关系。方法:Langendorff灌流模拟心肌缺血和再灌注,观察激活或阻断α1 受体不同时相心肌线粒体的变化。结果:缺血前使用 phenylephrine线粒体损害程度最低,与正常对照组比较差异无统计学意义;缺血期间加用 phenylephrine,损害程度最重;再灌注时使用 pheny lephrine,损害程度介于上述两组之间。全程使用 phenylephrine,心肌损害程度与预处理组相似;prazosin缺血前使用对线粒体无影响;缺血期间加用prazosin损害程度与正常对照组相差不大;再灌注时使用prazosin,损害程度明显加重,程度仅次于全程给药组。结论:缺血前激活、缺血期间阻断α1 受体可保护心肌。再灌注时激活α1 受体效应不明确,但阻断α1 受体有害。Objective: The purpose of our study is to investigate the relation between α 1 -adrenoceptors and mitochondria during different status blood supply. Method:Ischemia/reperfusion model was obtained according to Langendorff method. Activating or blockingα 1 -adrenoceptors, mitochondria was observed. Result:Mitochodria injury was the mildest if phenylephrine were administered before ischmia. Phenylephrine given during ischmia, Mitochodria injury was the most serious among all groups. During reperfusion , the degree of injury was in the middle range of previous two groups. However, group of the entire experimental period was similar to ischemic precondition group. Prazosin given before ischemia was no effect. Its' effect during ischmia was similar to one in the control, but it was detrimental during reperfusion next to drug given in the entire experiment period.Conclusion:The findings demonstrated that the effect of activating or blocking α 1 -adrenoceptors depends on blood supply status of myocardium.Activating α 1 -adrenoceptors before ischemia was protective but was detrimental during ischemia. Blocking α 1 -adrenoceptors was beneficial during ischemia . Activating α 1 -adrenoceptors during reperfusion did not significantly influence myocardial injury, but blocking it was detrimental during reperfusion.

关 键 词：受体 肾上腺素能α1 心肌 线粒体 超微病理学 

分 类 号：R542.2[医药卫生—心血管疾病]