一种水溶性温敏共聚高分子的制备及溶液性质研究  

Preparation and Solution Properties of a Thermo-sensitive Aqueous Solubility Copolyme

作　　者：尹唯斯[1] 杨琥[1] 郑云[1] 王治流[1] 程镕时[1] 

机构地区：[1]南京大学化学化工学院介观化学教育部重点实验室高分子科学与工程系,南京210093

出　　处：《南京大学学报（自然科学版）》2005年第2期133-138,共6页Journal of Nanjing University（Natural Science）

基　　金：国家自然科学基金面上基金(2020400420474026);国家教育部博士点基金(20030284003)

摘　　要：　以N-异丙基丙烯酰胺和N-异丙基甲基丙烯酰胺为共聚单体,合成了一种在水溶液中具有与人体正常体温37℃一致的相转变温度的共聚化合物.利用动态光散射技术研究了这一特殊共聚物在水溶液中高分子链构象行为随温度的变化情况.A series of copolymers of N-isopropylacrylamide (NIPAM) and N-isopropylmethacrylamide (NIPMAM) with different monomer ratios have been prepared well, whose transition temperature in aqueous solution have been measured by MicroCalorimenter respectively. The relationship of the transition temperature and their compositions have been set, and our results is coincident with those reported in ref.[1] However, it is interesting that when the composition of the NIPMAM monomer in the mixture monomers before polymerization was about 25%, a special thermosensitive copolymer, with a transition temperature near human heat of 37 ℃ in water, has been obtained successfully. In this article, the temperature dependence of the special copolymer conformation in water has been investigated by Dynamic Laser Light Scattering (DLLS) at the concentration higher than the critical concentration of the self-association according to cluster theory. From the DLLS experimental results, it was found that the hydrodynamic radius distribution of the polymer in solution had changed with temperature increasing. It was believed that there were two factors which affected the copolymer conformation and its size distribution in solution: one is the polymer coil shrinking, and the other is the self-association of the interchain.

关 键 词：聚N-异丙基丙烯酰胺-N-异丙基甲基丙烯酰胺共聚物 流体力学半径 自缔合行为 动态激光光散射 

分 类 号：O631.4[理学—高分子化学]