云南健康人群巴尔通体感染的血清学评估  

Evaluation of Human Seroreactivity to Bartonella Species amongHealthy Individuals in Yunnan, China

作　　者：白瑛[1] M.YKosoy 白鹤鸣[1] 杨幸[1] 

机构地区：[1]云南省流行病防治研究所,671000 [2]美国疾病控制中心虫媒传染病分部

出　　处：《中国地方病防治》2004年第1期17-19,共3页Chinese Journal of Control of Endemic Diseases

摘　　要：目的 了解巴尔通体(Bartonella)在云南健康人群中的感染情况。方法 以间接免疫荧光抗体测定法(IFA)对30份有可疑鼠类接触史的云南健康人血清行以抗Bartonella Elizabethae等9种不同巴尔通体抗原的IgM和IgM抗体水平测定。结果 有5份血清对4种抗原发生反应,其中1份抗 B.elizabethae IgG阳性(1:128);其他为抗Neotoma IgG(1:128)或IgM及抗Al IgM(≥1:32)阳性。结论 巴尔通体感染存在于人群中,考虑目前临床众多不明原因发热患者及一些临床疑难杂症下B.elizabethae及其他鼠传巴尔通体的感染有关,有必要在云南乃至全国范围内进行巴尔通体人群感染状况的进一步调查,对病人的治疗提出行之有效的科学的方法。Objective Learning about seroreactivity to Bartonella spp. among healthy individuals in Yunnan. Methods 30 sera from healthy people who were potentially exposed to rats in Yunan have been selected to test for Bartonella antibodies by Indirect Immunofluorecence Assay (IFA). IgM and JgG antibodies were tested separately against 9 different Bartonella antigens. Results Totally, 5 sera were positive to different Bartonella antigens. Both IgM and IgG antibodies were found against B. elizabethae, Neotoma, Al, and B2. JgG antibodies wen; found with titer 1:128 in one sample. Conclusions Baronella infection, especially B. elizabethae infection happens to people in Yunnan. It s probably responsible for those undiagnosed febrile illness. Further investigation for rodent -associated Bartonella infection is required in this area and the whole nation.

关 键 词：巴尔通体感染 健康人群 抗B 阳性 抗原 治疗 血清学 感染情况 抗N 发生 

分 类 号：R512[医药卫生—内科学] R378[医药卫生—临床医学]