儿童咳嗽变异性哮喘气道反应性的测定及意义  

Measurement of airway reactivity in children with cough variant asthma and its significance

作　　者：冯敏之[1] 黄东明[1] 肖晓雄[1] 崔碧云[1] 

机构地区：[1]广东省中山市博爱医院儿科,528402

出　　处：《医学文选》2004年第3期273-274,共2页Anthology of Medicine

摘　　要：目的　探讨儿童咳嗽变异性哮喘 ( CVA)气道反应性的特征 ,提高 CVA的诊断率。方法　以二磷酸组胺为气道激发剂进行支气管激发试验 ,观察 40例 CVA、45例支气管哮喘 (缓解期 )和 3 0例急性支气管炎儿童的气道反应性。结果　激发试验中 CVA、支气管哮喘患儿均显阳性。 40例 CVA中 PD2 0 FEV1 为极轻度 2 9例 ,轻度 8例 ,中度 3例 ;45例支气管哮喘中 PD2 0 FEV1 为极轻度 3例 ,轻度 7例 ,中度 2 6例 ,重度 9例 ;3 0例急性支气管炎病儿中 ,支气管激发试验 2 8例阴性 ,占 93 .3 %,2例阳性 ,占 6.7%,2例阳性的急性支气管炎患儿 PD2 0 FEV1 均呈极轻度。可见 CVA患儿的气道高反应性低于支气管哮喘患儿而高于急性支气管炎患者 ( P <0 .0 1 )。结论　CVA患儿气道高反应性程度低 ,病情相对较轻 ,如能早期诊断 。Objective To investigate the characters of airway reactivity in cough variant asthma(CVA)in children and improve the clinical diagnosis ability for CVA.Methods The bronchus excitation test was made using histamine phosphate excitant.The airway reactive ties for 40 cases of CVA,45 cases bronchial asthma remission phase and 30 subjects of acute bronchitis in childre were measured.Results IT was found that all the CVA and bronchial asthma were positive.29 cases out of 40 cases in PD 20 FEV 1 were fearfully mild,8 cases were mild,3 cases moderate.There were 3 cases terribly mild,7 mild,26 moderate and 9 severe out of 45 cases with bronchial asthma.28 out of 30 cases with acute bronchitis were negative,2 cases were very mild.It means that the bronchial hyperresponsiveness in children with CVA was lower than that with bronchial asthma and higher than that with acute bronchitis(χ 2=168 6,P<0 01).Conclusions There are low level of the bronchial hyperresponsiveness and the mild patient's condition in children with CVA,if we can diagnose earilier and treat properly,the prognosis is good.

关 键 词：气道反应性 儿童 咳嗽变异性哮喘 支气管哮喘 急性支气管炎 

分 类 号：R725.6[医药卫生—儿科]