指甲肌酐测定在药物不良反应监测中的作用  

Applicance of Fingernail in Supervising Adverse Drug Reaction

作　　者：何心[1] 刘旭光[1] 曲修进[1] 韩志君[1] 冯承善[1] 

机构地区：[1]黑龙江省医院临床药学研究所,150036

出　　处：《药物流行病学杂志》1994年第3期135-136,共2页Chinese Journal of Pharmacoepidemiology

摘　　要：文章对10例健康人和7例急性肾功能衰竭(ARF)及8例慢性肾功能衰竭(CRF)患者的指甲肌酐和血肌酐进行测定,结果表明:健康人与ARF的指甲肌酐无显著差异(P>0.05),而ARF与CRF的指甲肌酐则有显著性差异(P<0.01);健康人与ARF的血肌酐有显著性差异(P<0.01),而ARF和CRF的血肌酐则无显著性差异(P>0.05).由此可见,血肌酐测定值不能作为急慢性肾功能衰竭的判别指标,而指甲肌酐的测定则可以作为鉴别急、慢性肾竭的指标.测定指甲肌酐可作为药物不良反应监测的重要指标.The authors checked fingernail creatinine and serum creatinine of 10 normal persons, 7 ARF patients and 8 CRF patients, draws the conclusion: The result of checking fingernail creatinin is no notable difference between normal persons and ARF patients (P>0.05), while is obvious difference between ARF and CRF patients (P<0. 01); The result of checking serumcreatinine is notable difference between normal persons and ARF patients(P<0.01) and no obvious difference between ARF and CRF patients (P>0. 05). So it can be seen that the serum creatinine value can not determine whether the kidneys weakening is acute or chronic, but the checking of fingernail can judge kidneys weakening is caused by adverse drug reaction or not, it can be used as one of the important norms in supervising ADRs.

关 键 词：指甲肌酐 血肌酐 药物副作用 

分 类 号：R969[医药卫生—药理学]