自身免疫性甲状腺炎89例临床病理分析  

Autoimmune thyroiditis: clinicopathological analyses of 89 cases

作　　者：骆利康[1] 何晓燕 蒋树汉 徐文兴[1] 

机构地区：[1]衢州市人民医院病理科,浙江衢州324002 [2]巨化市医院病理科,浙江巨化324004 [3]开化县人民医院病理科,浙江开化324300

出　　处：《诊断病理学杂志》2004年第4期226-227,I060,共3页Chinese Journal of Diagnostic Pathology

摘　　要：目的　探讨自身免疫性甲状腺炎的临床病理学特点。方法　回顾性分析 89例自身免疫性甲状腺炎的临床表现 ,病理变化。结果　女性 84例 ,男性 5例 ,年龄以 2 1～ 5 0岁 (73例 )为好发年龄段 ,病程多为 1～ 5年 (47例 ) ,甲状腺肿大同时伴甲状腺恶性肿瘤 7例。组织学表现 :甲状腺滤泡普遍萎缩 ,残留的滤泡增大嗜酸性变 ,大量淋巴细胞浸润并形成滤泡和大量纤维组织增生及玻璃样变。结论　自身免疫性甲状腺炎是一种与自身免疫性反应有关的疾病 ,病变早期临床常难以明确诊断 。Objective To investigate the clinical and pathological characteristics of autoimmune thyroiditis. Methods The clinical and pathological changes of 89 cases of autoimmune thyroiditis were reviewed and analysed. Results In all cases there were 84 females and 5 males,with two peak incidence, decades of the third (29 cases) and fifth (33 cases).The course in most cases ranged from 1 to 5 years,and size increase subsequent with malignant neoplasm took place in 4 cases.Microscopically diffused follicles atrophy was seen,and plasma of the remanent follicle cells showed oncocytic changes.Lymphocytes infiltrated and germinal center formed.Hyperplasia of fibrous tissue followed by hyaline degeneration was also found. Conclusion Autoimmune thyroiditis is a disease related with autoimmune reaction.It is difficult to diagnose it in early stage,and fine needle aspiration is of great value.

关 键 词：自身免疫性甲状腺炎 诊断 临床病理分析 滤泡 细针穿刺活检 纤维组织增生 性反应 残留 病变 

分 类 号：R581.4[医药卫生—内分泌] R775[医药卫生—内科学]