白花前胡中前胡香豆素D和前胡香豆素E的分离和鉴定  

ISOLATLON AND STRUCTRAL ELUCIDATION OF QIANHUCOUMAKIN D AND QIANHUCOUMARIN E FROM PEUCEDANUM PRAERUPTORUM

作　　者：孔令义[1] 李铣[1] 裴月湖[1] 朱廷儒[1] 

机构地区：[1]沈阳药学院天然药物研究室,中国药科大学植化教研室

出　　处：《药学学报》1994年第1期49-54,共6页Acta Pharmaceutica Sinica

摘　　要：从中药白花前胡（ＰｅｕｃｅｄａｎｕｍＰｒａｅｒｕｐｔｏｒｕｍＤｕｎｎ）根中分到５个化合物，经理化常数、波谱数据及化学反应分别鉴定为前胡香豆素Ｄ（Ｉ），Ｐｄ－Ｉｂ（ＩＩ），前胡香豆素Ｅ（ＩＩＩ），ｎｏｄａｋｅｎｅｔｉｎ（ＩＶ）和ｓｃｏｐｏｌｅｔｉｎ（Ｖ）。其中化合物Ｉ和ＩＩＩ为两个新化合物，与巳知化合物凯林内酯的化学沟通确定了其绝对构型，其化学结构分别为３＇（Ｓ），４＇（Ｓ）－二乙酰氧基－３＇，４＇－二氢邪蒿内酯（Ｉ）和３＇（Ｒ）－惕各酰氧基－４＇－酮基－３＇，４＇－二氢邪蒿内酯（ＩＩＩ）。化合物ＩＶ和Ｖ为首次从该植物中分离得到。通过ＤＥＰＴ，１Ｈ－１ＨＣＯＳＹ和１３Ｃ－１ＨＣＯＳＹ等实验归属了ＩＩ的碳氢信号。Five compounds were isolated from the traditional Chinese medicine Qianhu, rootsof Peucedanum praeruptorum Dunn. Their structures were identified as qianhucoumarin D(I) , PD-Ib(II), qianhucoumarin E(III) ,nodakenetin(IV)and scopoletin(V)by physico-chemical constants andspectral analyses(UV ,IR,lHNMR,13CNMR , 2D-NMR,EIMS).I and IIl are new compounds,their structures were elucidated as 3'(S),4'(S)-diacetoxy-3',4'-dihydroseselin(1)and 3'(R)-tigloyloxy-4'-keto-3',4'-dihydroseselin(III)and the absolute configurations were determined bychemical correlations with known compounds.IV and V were first isolated from this plant. The1HNMR and 13CNMR signals of Il were assigned definitely by the experiments of DEPT,1H-1HCOSY and 13C-1H COSY.

关 键 词：白花前胡 前胡香豆素 分离 鉴定 

分 类 号：R284.2[医药卫生—中药学]