关附甲素抑制犬冠脉结扎引起的心律失常  

GUANFU BAsE A INHIBIT THE POST- INFARCTION VENTRICULAR ARRHYTHM IAS INDOGS

作　　者：王友群[1] 苏玲[1] 龚国清[1] 刘静涵[1] 

机构地区：[1]南京中国药科大学药理研究室

出　　处：《药学学报》1994年第2期141-144,共4页Acta Pharmaceutica Sinica

摘　　要：关附甲素抑制犬冠脉结扎引起的心律失常王友群，苏玲，龚国清，刘静涵（南京中国药科大学药理研究室，中草药化学教研室２１０００９）关附甲素（ｇｕａｎｆｕｂａｓｅＡ，ＧＦＡ）是从关白附子中提取的一种二萜类生物碱（１，２）。现已发现它能抑制乌头碱、哇巴因和氯化...Harris tow- stage left anterior coronary ligation was performed in anesthetizeddogs.After twenty hours,severe ventricular arrhythmias were recorded under conscious state.Cumu-lative intravenous injections of guanfu base A,a new alkaloid isolated from the tuber of Aconitumcoreanum in China,from 1 0 to 4 0 mg· kg-1produced remarkable antiarrhythmic effect lasting over30 min and a moderate reduction of heart rate. The P-R interval,QRS complex and Q-Tinterval ofthe sinus rhythm were not significantly altered.The antiarrhythmic potency of guanfu base A in thismodel was found to be about one third that of quinidine.

关 键 词：关附甲素 心律失常 白附子 附子 

分 类 号：R285.5[医药卫生—中药学]