大青叶类药材及其制剂质量控制的研究  

STUDY ON THEQUALITY CONTROL OF DAQINGYES(FOLIUM STROBILANTHES),BANLANGEN(RADIX STROBILANTHES)AND THEIR PREPARATIONS

作　　者：李玲[1] 董同义 李修禄[1] 乔传卓 

机构地区：[1]上海第二军医大学药学院

出　　处：《药学学报》1994年第2期128-131,共4页Acta Pharmaceutica Sinica

摘　　要：首次建议以抗病毒有效成分４（３Ｈ）－喹唑酮［４（３Ｈ－ｑｕｉｎａｚｏｌｉｎｏｎｅ］作为大青叶、板蓝根类药材及制剂的质量控制指标。药理实验结果证明此成分有抗病毒活性及增强机体免疫力的活性，为此类药材和制剂的质量控制提供了更科学和可靠的依据。本文用高效液相色谱法对药材和制剂中的４（３Ｈ）－喹唑酮作了含量分析，取得满意结果。This paper suggests that the antiviral active constituent 4(3H)-quinazolinone maybe used as a quality control standard for the Chinese herbal drugs Daqingye(Folium strobilanthes)and Banlangen(Radix strobilanthes) as well as its preparations.4(3H)- quinazolinone was found for thefirst time from the above mentioned Chinese herbal drugs. Pharmacoiogical tests demonstrated that ithas antiviral and immuno regulating activities.This provides a reliable basis for the quality control ofDaqingye,Balangen and its preparations.Its con tentis determined by HPLC. The method showedgood linearity(r=0.9998,n= 5 ) in the range of 0.25～50μg/ml of 4(3H)-quinazolinone.Theaverage recovery was about 96～98%with RSD<1.69%(n=3).HPLC conditions:column : LiChrosorb RP 1 8(10μm);mobile phase:methanol一water(40:60);detection wavelength;230 nm。

关 键 词：大青叶 板蓝根 高效液相色谱 

分 类 号：R284.1[医药卫生—中药学]