云南红豆杉中四个新紫杉烷类二萜化合物的分离和结构鉴定  

I SOLATION AND STRUCTURAL ELUCIDATION OF FOUR NEW TAXANE DITERPENOIDS FRON TAXUS YUNNANENSIS

作　　者：陈未名[1] 张佩玲[1] 周金云[1] 

机构地区：[1]中国医学科学院,中国协和医科大学药物研究所

出　　处：《药学学报》1994年第3期207-214,共8页Acta Pharmaceutica Sinica

摘　　要：自云南红豆杉（ＴａｘｕｓｙｕｎｎａｎｅｎｓｉｓＣｈｅｎｇｅｔＬ．Ｋ．Ｆｕ）树皮的二氯甲烷提取部分又分离得到７个紫杉烷类二萜和生物碱，经光谱（ＩＲ，ＭＳ，１ＨＮＭＲ，１Ｈ－１Ｈ’ＣＯＳＹ，１３Ｃ－１ＨＣＯＳＹ）解析推定４个新的紫杉烷类二萜涨化合物的结构为５－ｄｅｃｉｎｎａｍｏｙｌ－１１－ａｃｅｔｙｌ－１９－ｈｙｄｒｏｘｙｌｔａｘａｇｉｆｉｎｅ（Ｉ），２－ｄｅａｃｅｔｏｘｙ－５．ｄｅｃｉｎｎａｍｏｙｌｔａｘｉｎｉｎｅＪ（ＩＩ），１－ｈｙｄｒｏｘｙ－２，７，９－ｔｒｉｄｅａｃｅｔｙｌｂａｃｃａｔｉｎＩ（ＩＶ）和７－ｘｙＩｏｓｙｌ－１０－ｄｅａｃｅｔｙｌｂａｃｃａｔｉｎＩＩＩ（ＶＩＩ），３个已知的紫杉烷类二苑和生物碱是５－ｄｅｃｉｎｎａｍｏｙＩｔａｘｉｎｉｎｅＪ（ＩＩＩ），７－ｘｙｌｏｓｙｌｔａｘｏｌ（Ｖ）和７－ｘｙｌｏｓｙｌｃｅｐｈａｌｏｍａｎｎｉｎｅ（ＶＩ），它们是首次从该植物中得到。Seven taxane diterpen oids and alk aloids have been isolated from the ethanolicextract of the bark of Taxus yunnanensis Cheng et L.K.Fu. Three were identified as the known taxanes:5-decinnamovyl taxinineJ ( III),7-xylosyl taxol(V)and 7-xylosyl cephalomannine(VI ).Thestructures of four new compounds were elucidated as 5- decinnamoyl-11-acetyl-19- hydroxy taxagifine(I),2- deacety-5- decinnamoyltaxinine J(II ,1-hydroxy-2,7,9-trideacetylbaccatin I(IV )and7- xylosyl-10- deacetoxybaccatin III(VII)by spectroscopic methods(MS,1H NMR,1H-1H COSY,13CNMR, 13C-1HCOSY).

关 键 词：云南红豆杉 紫杉烷类 二萜衍生物 

分 类 号：R284.2[医药卫生—中药学]